DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, In Kyu | ko |
dc.contributor.author | Song, Hyerin | ko |
dc.contributor.author | Kim, Hyerim | ko |
dc.contributor.author | Kim, Ik Soo | ko |
dc.contributor.author | Na Ly Tran | ko |
dc.contributor.author | Kim, Sang-Heon | ko |
dc.contributor.author | Oh, Seung Ja | ko |
dc.contributor.author | Lee, Ji Min | ko |
dc.date.accessioned | 2022-02-21T06:41:24Z | - |
dc.date.available | 2022-02-21T06:41:24Z | - |
dc.date.created | 2022-02-21 | - |
dc.date.created | 2022-02-21 | - |
dc.date.created | 2022-02-21 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.citation | CANCERS, v.12, no.7 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | http://hdl.handle.net/10203/292312 | - |
dc.description.abstract | Retinoic acid-related orphan receptor alpha (ROR alpha) functions as a transcription factor for various biological processes, including circadian rhythm, inflammation, cancer, and lipid metabolism. Here, we demonstrate that ROR alpha is crucial for maintaining cholesterol homeostasis in CD8(+)T cells by attenuating NF-kappa B transcriptional activity. Cholesterol sulfate, the established natural agonist of ROR alpha, exhibits cellular cytotoxicity on, and increased effector responses in, CD8(+)T cells. Transcript analysis reveals that the suppression of ROR alpha leads to the upregulation of NF-kappa B target genes in T cells. Chromatin immunoprecipitation analysis was used to determine the corecruitment of ROR alpha and histone deacetylase (HDAC) on NF-kappa B target promoters and the subsequent dismissal of coactivators for transcriptional repression. We demonstrate that ROR alpha/HDAC-mediated attenuation of NF-kappa B signaling controls the balance of cholesterol metabolism in CD8(+)T cells, and that therapeutic strategies targeting this epigenetic regulation could be beneficial to the treatment of solid tumors including colon cancers. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | ROR alpha Regulates Cholesterol Metabolism of CD8(+) T Cells for Anticancer Immunity | - |
dc.type | Article | - |
dc.identifier.wosid | 000557148900001 | - |
dc.identifier.scopusid | 2-s2.0-85087156954 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 7 | - |
dc.citation.publicationname | CANCERS | - |
dc.identifier.doi | 10.3390/cancers12071733 | - |
dc.contributor.localauthor | Lee, Ji Min | - |
dc.contributor.nonIdAuthor | Lee, In Kyu | - |
dc.contributor.nonIdAuthor | Song, Hyerin | - |
dc.contributor.nonIdAuthor | Kim, Hyerim | - |
dc.contributor.nonIdAuthor | Kim, Ik Soo | - |
dc.contributor.nonIdAuthor | Na Ly Tran | - |
dc.contributor.nonIdAuthor | Kim, Sang-Heon | - |
dc.contributor.nonIdAuthor | Oh, Seung Ja | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Cholesterol | - |
dc.subject.keywordAuthor | CD8(+)T cell | - |
dc.subject.keywordAuthor | ROR alpha | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordPlus | NUCLEAR RECEPTORS | - |
dc.subject.keywordPlus | PPAR-GAMMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | BLOCKADE | - |
dc.subject.keywordPlus | TUMORS | - |
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