DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hou, Jingang | ko |
dc.contributor.author | Jeon, Byeongmin | ko |
dc.contributor.author | Bae, Jongin | ko |
dc.contributor.author | Yun, Yeejin | ko |
dc.contributor.author | Kim, Daeun | ko |
dc.contributor.author | Chang, Boyoon | ko |
dc.contributor.author | Kim, Sungyeon | ko |
dc.contributor.author | Kim, Sunchang | ko |
dc.date.accessioned | 2022-01-24T06:40:46Z | - |
dc.date.available | 2022-01-24T06:40:46Z | - |
dc.date.created | 2022-01-24 | - |
dc.date.created | 2022-01-24 | - |
dc.date.created | 2022-01-24 | - |
dc.date.created | 2022-01-24 | - |
dc.date.issued | 2022-01 | - |
dc.identifier.citation | JOURNAL OF GINSENG RESEARCH, v.46, no.1, pp.79 - 90 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.uri | http://hdl.handle.net/10203/292004 | - |
dc.description.abstract | Background: Herbal medicines are popular approaches to capably prevent and treat obesity and its related diseases. Excessive exposure to dietary lipids causes oxidative stress and inflammation, which possibly induces cellular senescence and contribute the damaging effects in brain. The potential roles of selective enhanced ginsenoside in regulating high fat diet (HFD)-induced brain damage remain unknown. Methods: The protection function of Ginsenoside F1-enhanced mixture (SGB121) was evaluated by in vivo and in vitro experiments. Human primary astrocytes and SH-SY5Y cells were treated with palmitic acid conjugated Bovine Serum Albumin, and the effects of SGB121 were determined by MTT and lipid uptake assays. For in vivo tests, C57BL/6J mice were fed with high fat diet for 3 months with or without SGB121 administration. Thereafter, immunohistochemistry, western blot, PCR and ELISA assays were conducted with brain tissues. Results and conclusion: SGB121 selectively suppressed HFD-induced oxidative stress and cellular senescence in brain, and reduced subsequent inflammation responses manifested by abrogated secretion of IL-6, IL-1b and TNFa via NF-kB signaling pathway. Interestingly, SGB121 protects against HFD-induced damage by improving mitophagy and endoplasmic reticulum-stress associated autophagy flux and inhibiting apoptosis. In addition, SGB121 regulates lipid uptake and accumulation by FATP4 and PPARa. SGB121 significantly abates excessively phosphorylated tau protein in the cortex and GFAP activation in corpus callosum. Together, our results suggest that SGB121 is able to favor the resistance of brain to HFD-induced damage, therefore provide explicit evidence of the potential to be a functional food. (c) 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.language | English | - |
dc.publisher | KOREAN SOC GINSENG | - |
dc.title | High fat diet-induced brain damaging effects through autophagy-mediated senescence, inflammation and apoptosis mitigated by ginsenoside F1-enhanced mixture | - |
dc.title.alternative | High fat diet-induced brain damaging effects through autophagy-mediated senescence, inflammation and apoptosis mitigated by ginsenoside F1-enhanced mixture | - |
dc.type | Article | - |
dc.identifier.wosid | 000742142200009 | - |
dc.identifier.scopusid | 2-s2.0-85106235623 | - |
dc.type.rims | ART | - |
dc.citation.volume | 46 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 79 | - |
dc.citation.endingpage | 90 | - |
dc.citation.publicationname | JOURNAL OF GINSENG RESEARCH | - |
dc.identifier.doi | 10.1016/j.jgr.2021.04.002 | - |
dc.identifier.kciid | ART002829736 | - |
dc.contributor.localauthor | Kim, Sunchang | - |
dc.contributor.nonIdAuthor | Hou, Jingang | - |
dc.contributor.nonIdAuthor | Bae, Jongin | - |
dc.contributor.nonIdAuthor | Kim, Daeun | - |
dc.contributor.nonIdAuthor | Chang, Boyoon | - |
dc.contributor.nonIdAuthor | Kim, Sungyeon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | Brain damage | - |
dc.subject.keywordAuthor | SGB121 | - |
dc.subject.keywordAuthor | High fat diet | - |
dc.subject.keywordAuthor | Senescence | - |
dc.subject.keywordPlus | HEAT-SHOCK PROTEINS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | CELLULAR SENESCENCE | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | MITOCHONDRIAL | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MICROGLIA | - |
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