DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jeong Seok | ko |
dc.contributor.author | Im, Churl Hyun | ko |
dc.contributor.author | Lee, Sang Jin | ko |
dc.contributor.author | Choi, Ji Yong | ko |
dc.contributor.author | Han, Jung Min | ko |
dc.contributor.author | Kim, Sunghoon | ko |
dc.contributor.author | Kim, Dong Jo | ko |
dc.contributor.author | Park, Taesung | ko |
dc.contributor.author | Lee, Eun Young | ko |
dc.contributor.author | Song, Yeong Wook | ko |
dc.date.accessioned | 2022-01-06T06:40:36Z | - |
dc.date.available | 2022-01-06T06:40:36Z | - |
dc.date.created | 2022-01-06 | - |
dc.date.created | 2022-01-06 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v.22, no.5, pp.905 - 912 | - |
dc.identifier.issn | 1756-1841 | - |
dc.identifier.uri | http://hdl.handle.net/10203/291615 | - |
dc.description.abstract | Aim To investigate the clinical implications of a genetic polymorphism in glycoprotein 96 (GP96), by analyzing the association between the genotype and haplotype of GP96 with systemic lupus erythematosus (SLE). Method We analyzed cell-surface expression of GP96 in peripheral blood mononuclear cells (PBMCs) and serum titer of anti-GP96 antibody of SLE patients. Single nucleotide polymorphisms and deletion mutants of GP96 were detected by two-dimensional gene scanning (TDGS). Odds ratios with 95% confidence intervals (CI) were determined for each genotype and haplotype through the chi-square test. Results In total, 216 Korean SLE patients and 215 age- and sex-matched healthy controls were enrolled. In SLE patients, as opposed to healthy controls, cell-surface expression of GP96 among human leukocyte antigen-DR+ PBMCs (76.4% vs 45.5%, respectively, P < 0.001) and serum anti-GP96 antibody titers (0.98 vs 0.50, respectively, P = 0.012) increased. TDGS revealed six polymorphic sites in GP96, two of which were significantly associated with SLE (exon 1, g.-7C>G, odds ratio [OR] 1.78, 95% CI 1.16-2.75, P = 0.009; exon 17, g.17009_17011del, OR 1.76, 95% CI 1.18-2.64, P = 0.006). Two haplotypes (121111, 211212) were strongly associated with SLE (OR 8.92, 95% CI 1.10-72.6, P = 0.041; OR 3.03, 95% CI 1.22-7.50, P = 0.017, respectively) and specific clinical manifestations (discoid rash, arthritis, renal disorder, neurologic disorder, and hematologic disorder). Haplotype-based analysis revealed a stronger association between GP96 and SLE than did genotype-based analysis. Conclusion The two polymorphisms, each in exons 1 and 17 of GP96 are potential genetic risk factors of SLE. Two haplotypes 121111 and 211212 are related to not only SLE but also specific clinical manifestations. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.title | Glycoprotein 96 polymorphisms are associated with the risk of systemic lupus erythematosus: A case-control study | - |
dc.type | Article | - |
dc.identifier.wosid | 000467262600018 | - |
dc.identifier.scopusid | 2-s2.0-85062971847 | - |
dc.type.rims | ART | - |
dc.citation.volume | 22 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 905 | - |
dc.citation.endingpage | 912 | - |
dc.citation.publicationname | INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | - |
dc.identifier.doi | 10.1111/1756-185X.13515 | - |
dc.contributor.localauthor | Lee, Jeong Seok | - |
dc.contributor.nonIdAuthor | Im, Churl Hyun | - |
dc.contributor.nonIdAuthor | Lee, Sang Jin | - |
dc.contributor.nonIdAuthor | Choi, Ji Yong | - |
dc.contributor.nonIdAuthor | Han, Jung Min | - |
dc.contributor.nonIdAuthor | Kim, Sunghoon | - |
dc.contributor.nonIdAuthor | Kim, Dong Jo | - |
dc.contributor.nonIdAuthor | Park, Taesung | - |
dc.contributor.nonIdAuthor | Lee, Eun Young | - |
dc.contributor.nonIdAuthor | Song, Yeong Wook | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | GP96 | - |
dc.subject.keywordAuthor | heat shock protein | - |
dc.subject.keywordAuthor | single nucleotide polymorphism | - |
dc.subject.keywordAuthor | systemic lupus erythematosus | - |
dc.subject.keywordAuthor | two-dimensional gene scanning | - |
dc.subject.keywordPlus | SHOCK-PROTEIN GP96 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | HSP90B1 | - |
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