(A) study on the synthesis of nanostructured materials and fabrication of microfluidics devices for biosensor application = 바이오센서로의 응용을 위한 나노구조물의 합성과 마이크로플루딕 장치 제작에 관한 연구

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Microfluidic devices and nano materials play key roles in the emerging biosensor applications such as lab-on-a-chip, which include pretreatment and purification of protein sample, and diagnosis and therapy of disease. Recently, microfluidic devices for biological sample pretreatment have become important in the design of analytical devices for high-throughput applications such as functional validation of proteins and peptides in large-scale proteome characterizations. In addition, nano materials for diagnosis and therapy are young and rapid emerging field such as point-of-care (POC) biosensor, tumor pretargeting agent, drug delivery vehicle and diagnostic imaging agent. In this study, microvalves based on ionic polymer metal composite (IPMC) were developed for microfluidic application, and multi-functional polydiacetylene-modified reduced graphene oxide (PDA/RGO) were prepared for the nano materials for biosensor applications. First, simple and highly efficient microvalve systems based on IPMC diaphragm actuator has been developed. Our microvalve system operates when ‘open’ and ‘close’ voltage are applied. Displacement of IPMC in the microvalve was measured by laser displacement meter. By applying open and close voltages, the operation of the valve becomes faster. Fluorescence images of the flow in the fabricated IPMC microvalve system showed a successful operation of flow control in the microfluidic channel. Second, graphene nano sheet hybridized with polydiacetylene (PDA) was explored as the electrochemical biosensor applications. Self-assembly and photo-polymerization chemistry of diacetylenic monomers on reduced graphene oxide (RGO) for noncovalent functionalization was used for high solubility and further functionality of graphene in water. This enabled regular graphene micropatterns on large substrates with chemical bonding and biological interactions. PDA/RGO nano hybrid demonstrates the formation of conjugated polymer on graphene for fluorescence and el...
Advisors
Kim, Do-Hyunresearcher김도현researcher
Description
한국과학기술원 : 생명화학공학과,
Publisher
한국과학기술원
Issue Date
2011
Identifier
466383/325007  / 020065109
Language
eng
Description

학위논문(박사) - 한국과학기술원 : 생명화학공학과, 2011.2, [ viii, 75 p. ]

Keywords

Polydiacetylene (PDA); Graphene; Microvalve; Ionic Polymer-Metal Composite (IPMC); Biosensor; 바이오센서; Polydiacetylene (PDA); 그래핀; 마이크로 밸브; Ionic Polymer-Metal Composite (IPMC)

URI
http://hdl.handle.net/10203/29118
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=466383&flag=dissertation
Appears in Collection
CBE-Theses_Ph.D.(박사논문)
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