Interhemispheric cortico-cortical pathway for sequential bimanual movements in mice

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Animals precisely coordinate their left and right limbs for various adaptive purposes. While the left and right limbs are clearly controlled by different cortical hemispheres, the neural mechanisms that determine the action sequence between them remains elusive. Here, we have established a novel head-fixed bimanual-press (biPress) sequence task in which mice sequentially press left and right pedals with their forelimbs in a prede-termined order. Using this motor task, we found that the motor cortical neurons responsible for the first press (1P) also generate independent motor signals for the second press (2P) by the opposite forelimb during the movement transitions between forelimbs. Projection-specific calcium imaging and optogenetic manipulation revealed these motor signals are transferred from one motor cortical hemisphere to the other via corticocorti-cal projections. Together, our results suggest the motor cortices coordinate sequential bimanual movements through corticocortical pathways. © 2021 Jeong, Lee et al.
Publisher
11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, USA, DC, 20036
Issue Date
2021-08
Language
English
Article Type
Article
Citation

ENEURO, v.8, no.4

ISSN
2373-2822
DOI
10.1523/eneuro.0200-21.2021
URI
http://hdl.handle.net/10203/289875
Appears in Collection
BiS-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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