DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koo, Bon Il | ko |
dc.contributor.author | Jin, Seon-Mi | ko |
dc.contributor.author | Kim, Hayeon | ko |
dc.contributor.author | Lee, Dong Jae | ko |
dc.contributor.author | Lee, Eunji | ko |
dc.contributor.author | Nam, Yoon Sung | ko |
dc.date.accessioned | 2021-11-23T06:41:54Z | - |
dc.date.available | 2021-11-23T06:41:54Z | - |
dc.date.created | 2021-09-24 | - |
dc.date.created | 2021-09-24 | - |
dc.date.created | 2021-09-24 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.citation | ADVANCED HEALTHCARE MATERIALS, v.10, no.22, pp.2101239 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.uri | http://hdl.handle.net/10203/289369 | - |
dc.description.abstract | Various lipid-based nanocarriers have been developed for the co-delivery of protein antigens with immunological adjuvants. However, their in vivo potency in vaccine delivery is limited by structural instability, which causes off-target delivery and low cross-presentation efficacies. Recent works employ covalent cross-linking to stabilize the lipid nanostructures, though the immunogenicity and side effects of chemically modified protein antigens and lipids can cause a long-lasting safety issue. Here robust "conjugation-free" multilamellar protein antigen-lipid hybrid nanovesicles (MPLVs) are introduced through the antigen-mediated self-assembly of unilamellar lipid vesicles for the co-delivery of protein antigens and immunologic adjuvants. The nanocarriers coated with monophosphoryl lipid A and hyaluronic acids elicit highly increase antigen-specific immune responses in vitro and in vivo. The MPLVs increase the generation of immunological surface markers and cytokines in mouse-derived bone-marrow dendritic cells compared to soluble antigens with adjuvants. Besides, the vaccination of mice with the MPLVs significantly increase the production of anti-antigen antibody and interferon-gamma via the activation of CD4(+) and CD8(+) T cells, respectively. These findings suggest that MPLVs can serve as a promising nanovaccine delivery platform for efficient antigen cross-presentation through the efficient co-delivery of protein antigens with adjuvants. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.title | Conjugation-Free Multilamellar Protein-Lipid Hybrid Vesicles for Multifaceted Immune Responses | - |
dc.type | Article | - |
dc.identifier.wosid | 000693186000001 | - |
dc.identifier.scopusid | 2-s2.0-85113918305 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 22 | - |
dc.citation.beginningpage | 2101239 | - |
dc.citation.publicationname | ADVANCED HEALTHCARE MATERIALS | - |
dc.identifier.doi | 10.1002/adhm.202101239 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Nam, Yoon Sung | - |
dc.contributor.nonIdAuthor | Jin, Seon-Mi | - |
dc.contributor.nonIdAuthor | Kim, Hayeon | - |
dc.contributor.nonIdAuthor | Lee, Eunji | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | antigen encapsulation | - |
dc.subject.keywordAuthor | monophosphoryl lipid A | - |
dc.subject.keywordAuthor | multilamellar self-assembly | - |
dc.subject.keywordAuthor | ovalbumin | - |
dc.subject.keywordAuthor | vaccine delivery | - |
dc.subject.keywordPlus | TRANSFECTION EFFICIENCY | - |
dc.subject.keywordPlus | SYNTHETIC VACCINES | - |
dc.subject.keywordPlus | CATIONIC LIPIDS | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | AGGREGATION | - |
dc.subject.keywordPlus | OVALBUMIN | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | ADJUVANTS | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.