Conjugation-Free Multilamellar Protein-Lipid Hybrid Vesicles for Multifaceted Immune Responses

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dc.contributor.authorKoo, Bon Ilko
dc.contributor.authorJin, Seon-Miko
dc.contributor.authorKim, Hayeonko
dc.contributor.authorLee, Dong Jaeko
dc.contributor.authorLee, Eunjiko
dc.contributor.authorNam, Yoon Sungko
dc.date.accessioned2021-11-23T06:41:54Z-
dc.date.available2021-11-23T06:41:54Z-
dc.date.created2021-09-24-
dc.date.created2021-09-24-
dc.date.created2021-09-24-
dc.date.issued2021-11-
dc.identifier.citationADVANCED HEALTHCARE MATERIALS, v.10, no.22, pp.2101239-
dc.identifier.issn2192-2640-
dc.identifier.urihttp://hdl.handle.net/10203/289369-
dc.description.abstractVarious lipid-based nanocarriers have been developed for the co-delivery of protein antigens with immunological adjuvants. However, their in vivo potency in vaccine delivery is limited by structural instability, which causes off-target delivery and low cross-presentation efficacies. Recent works employ covalent cross-linking to stabilize the lipid nanostructures, though the immunogenicity and side effects of chemically modified protein antigens and lipids can cause a long-lasting safety issue. Here robust "conjugation-free" multilamellar protein antigen-lipid hybrid nanovesicles (MPLVs) are introduced through the antigen-mediated self-assembly of unilamellar lipid vesicles for the co-delivery of protein antigens and immunologic adjuvants. The nanocarriers coated with monophosphoryl lipid A and hyaluronic acids elicit highly increase antigen-specific immune responses in vitro and in vivo. The MPLVs increase the generation of immunological surface markers and cytokines in mouse-derived bone-marrow dendritic cells compared to soluble antigens with adjuvants. Besides, the vaccination of mice with the MPLVs significantly increase the production of anti-antigen antibody and interferon-gamma via the activation of CD4(+) and CD8(+) T cells, respectively. These findings suggest that MPLVs can serve as a promising nanovaccine delivery platform for efficient antigen cross-presentation through the efficient co-delivery of protein antigens with adjuvants.-
dc.languageEnglish-
dc.publisherWILEY-
dc.titleConjugation-Free Multilamellar Protein-Lipid Hybrid Vesicles for Multifaceted Immune Responses-
dc.typeArticle-
dc.identifier.wosid000693186000001-
dc.identifier.scopusid2-s2.0-85113918305-
dc.type.rimsART-
dc.citation.volume10-
dc.citation.issue22-
dc.citation.beginningpage2101239-
dc.citation.publicationnameADVANCED HEALTHCARE MATERIALS-
dc.identifier.doi10.1002/adhm.202101239-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorNam, Yoon Sung-
dc.contributor.nonIdAuthorJin, Seon-Mi-
dc.contributor.nonIdAuthorKim, Hayeon-
dc.contributor.nonIdAuthorLee, Eunji-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorantigen encapsulation-
dc.subject.keywordAuthormonophosphoryl lipid A-
dc.subject.keywordAuthormultilamellar self-assembly-
dc.subject.keywordAuthorovalbumin-
dc.subject.keywordAuthorvaccine delivery-
dc.subject.keywordPlusTRANSFECTION EFFICIENCY-
dc.subject.keywordPlusSYNTHETIC VACCINES-
dc.subject.keywordPlusCATIONIC LIPIDS-
dc.subject.keywordPlusIFN-GAMMA-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusAGGREGATION-
dc.subject.keywordPlusOVALBUMIN-
dc.subject.keywordPlusMICROSPHERES-
dc.subject.keywordPlusMOLECULES-
dc.subject.keywordPlusADJUVANTS-
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