DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Boram | ko |
dc.contributor.author | Kanai, Makoto I. | ko |
dc.contributor.author | Oh, Yangkyun | ko |
dc.contributor.author | Kyung, Minsoo | ko |
dc.contributor.author | Kim, Eun-Kyoung | ko |
dc.contributor.author | Jang, In-Hwan | ko |
dc.contributor.author | Lee, Ji-Hoon | ko |
dc.contributor.author | Kim, Sang-Gyu | ko |
dc.contributor.author | Suh, Greg S. B. | ko |
dc.contributor.author | Lee, Won-Jae | ko |
dc.date.accessioned | 2021-11-19T06:41:04Z | - |
dc.date.available | 2021-11-19T06:41:04Z | - |
dc.date.created | 2021-05-17 | - |
dc.date.created | 2021-05-17 | - |
dc.date.created | 2021-05-17 | - |
dc.date.issued | 2021-05 | - |
dc.identifier.citation | NATURE, v.593, no.7860, pp.570 - 574 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | http://hdl.handle.net/10203/289281 | - |
dc.description.abstract | In Drosophila, an amino acid deficit triggers the expression of the neuropeptide CNMamide in gut enterocytes, which promotes a compensatory appetite for essential over non-essential amino acids, and this process is modulated by the microbiome. A balanced intake of macronutrients-protein, carbohydrate and fat-is essential for the well-being of organisms. An adequate calorific intake but with insufficient protein consumption can lead to several ailments, including kwashiorkor(1). Taste receptors (T1R1-T1R3)(2) can detect amino acids in the environment, and cellular sensors (Gcn2 and Tor)(3) monitor the levels of amino acids in the cell. When deprived of dietary protein, animals select a food source that contains a greater proportion of protein or essential amino acids (EAAs)(4). This suggests that food selection is geared towards achieving the target amount of a particular macronutrient with assistance of the EAA-specific hunger-driven response, which is poorly understood. Here we show in Drosophila that a microbiome-gut-brain axis detects a deficit of EAAs and stimulates a compensatory appetite for EAAs. We found that the neuropeptide CNMamide (CNMa)(5) was highly induced in enterocytes of the anterior midgut during protein deprivation. Silencing of the CNMa-CNMa receptor axis blocked the EAA-specific hunger-driven response in deprived flies. Furthermore, gnotobiotic flies bearing an EAA-producing symbiotic microbiome exhibited a reduced appetite for EAAs. By contrast, gnotobiotic flies with a mutant microbiome that did not produce leucine or other EAAs showed higher expression of CNMa and a greater compensatory appetite for EAAs. We propose that gut enterocytes sense the levels of diet- and microbiome-derived EAAs and communicate the EAA-deprived condition to the brain through CNMa. | - |
dc.language | English | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Response of the microbiome-gut-brain axis in Drosophila to amino acid deficit | - |
dc.type | Article | - |
dc.identifier.wosid | 000647544800002 | - |
dc.identifier.scopusid | 2-s2.0-85105209282 | - |
dc.type.rims | ART | - |
dc.citation.volume | 593 | - |
dc.citation.issue | 7860 | - |
dc.citation.beginningpage | 570 | - |
dc.citation.endingpage | 574 | - |
dc.citation.publicationname | NATURE | - |
dc.identifier.doi | 10.1038/s41586-021-03522-2 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Sang-Gyu | - |
dc.contributor.localauthor | Suh, Greg S. B. | - |
dc.contributor.nonIdAuthor | Kim, Boram | - |
dc.contributor.nonIdAuthor | Kanai, Makoto I. | - |
dc.contributor.nonIdAuthor | Oh, Yangkyun | - |
dc.contributor.nonIdAuthor | Kyung, Minsoo | - |
dc.contributor.nonIdAuthor | Kim, Eun-Kyoung | - |
dc.contributor.nonIdAuthor | Jang, In-Hwan | - |
dc.contributor.nonIdAuthor | Lee, Ji-Hoon | - |
dc.contributor.nonIdAuthor | Lee, Won-Jae | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
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