Redox Properties of Small Molecules Essential for Multiple Reactivities with Pathological Factors in Alzheimer's Disease

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Amyloid-beta, metal ions, and reactive oxygen species are linked to the pathology of Alzheimer's disease (AD). To identify their roles in the pathology of AD and control their pathological reactivities, various chemical tools have been developed. The redox-based strategy for designing small molecules with multiple reactivities toward pathogenic factors has recently received significant attention. This Account briefly illustrates our current understanding of diverse pathological elements associated with AD and their redox properties. Furthermore, we summarize some examples of redox-active small molecules with multifunctionality that were constructed by tuning electronic properties through incorporating substituents onto the backbones.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2021-10
Language
English
Article Type
Article
Citation

BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.42, no.10, pp.1277 - 1280

ISSN
0253-2964
DOI
10.1002/bkcs.12372
URI
http://hdl.handle.net/10203/288752
Appears in Collection
CH-Journal Papers(저널논문)
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