DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Hi Yuen | ko |
dc.contributor.author | Shin, Dong Woo | ko |
dc.contributor.author | Jung, Seung Moon | ko |
dc.contributor.author | Jeong, Yong | ko |
dc.contributor.author | Jeong, Bumseok | ko |
dc.contributor.author | Park, Chul Soon | ko |
dc.date.accessioned | 2021-10-31T06:41:22Z | - |
dc.date.available | 2021-10-31T06:41:22Z | - |
dc.date.created | 2021-10-31 | - |
dc.date.created | 2021-10-31 | - |
dc.date.created | 2021-10-31 | - |
dc.date.created | 2021-10-31 | - |
dc.date.created | 2021-10-31 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.citation | BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, v.7, no.6 | - |
dc.identifier.issn | 2057-1976 | - |
dc.identifier.uri | http://hdl.handle.net/10203/288459 | - |
dc.description.abstract | Objective. Electrical stimulation of the auricular vagus nerve is a non-invasive neuromodulation technique that has been used for various conditions, including depression, epilepsy, headaches, and cerebral ischemia. However, unwanted non-vagal nerve stimulations can occur because of diffused stimulations. The objective of this study is to develop a region-specific non-invasive vagus nerve stimulation (VNS) technique using the millimeter wave (MMW) as a stimulus for the auricular branch of the vagus nerve (ABVN). Approach. A numerical simulation was conducted to ascertain whether the MMW could excite the ABVN in the human outer-ear with a millimeter-scale spatial resolution. Additionally, MMW-induced neuronal responses in seven mice were evaluated. Transcutaneous auricular VNS (ta-VNS) was applied to the cymba conchae innervated by the AVBN using a 60-GHz continuous wave (CW). As a control, the auricle's exterior margin was stimulated and referred to as transcutaneous auricular non-vagus nerve stimulation (ta-nonVNS). During stimulation, the local field potential (LFP) in the nucleus tractus solitarii (NTS), an afferent vagal projection site, was recorded simultaneously. Main results. The ta-VNS with a stimulus level of 13 dBm showed a significant increase in the LFP power in the NTS. The mean increases in power (n = 7) in the gamma high and gamma very high bands were 8.6 +/- 2.0% and 18.2 +/- 5.9%, respectively. However, the ta-nonVNS with a stimulus level of 13 dBm showed a significant decrease in the LFP power in the NTS. The mean decreases in power in the beta and gamma low bands were 11.0 +/- 4.4% and 10.8 +/- 2.8%, respectively. These findings suggested that MMW stimulation clearly induced a different response according to the presence of ABVN. Significance. Selective auricular VNS is feasible using the MMW. This study provides the basis for the development of a new clinical treatment option using the stimulation of the ta-VNS with a square millimeter spatial resolution. | - |
dc.language | English | - |
dc.publisher | IOP Publishing Ltd | - |
dc.title | Feasibility study on transcutaneous auricular vagus nerve stimulation using millimeter waves | - |
dc.type | Article | - |
dc.identifier.scopusid | 2-s2.0-85117204359 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 6 | - |
dc.citation.publicationname | BIOMEDICAL PHYSICS & ENGINEERING EXPRESS | - |
dc.identifier.doi | 10.1088/2057-1976/ac2c54 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Jeong, Yong | - |
dc.contributor.localauthor | Jeong, Bumseok | - |
dc.contributor.localauthor | Park, Chul Soon | - |
dc.contributor.nonIdAuthor | Song, Hi Yuen | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | nucleus tractus solitarii | - |
dc.subject.keywordAuthor | non-invasive stimulation | - |
dc.subject.keywordAuthor | millimeter wave | - |
dc.subject.keywordAuthor | local field potential | - |
dc.subject.keywordAuthor | auricular branch of the vagus nerve | - |
dc.subject.keywordAuthor | transcutaneous auricular vagus nerve stimulation | - |
dc.subject.keywordPlus | ELECTRICAL-STIMULATION | - |
dc.subject.keywordPlus | EXTERNAL EAR | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | DEPENDENCE | - |
dc.subject.keywordPlus | MICE | - |
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