DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Eunsook | ko |
dc.contributor.author | Ryu, Ji Hyun | ko |
dc.contributor.author | Lee, Daiheon | ko |
dc.contributor.author | Lee, Haeshin | ko |
dc.date.accessioned | 2021-10-11T05:10:12Z | - |
dc.date.available | 2021-10-11T05:10:12Z | - |
dc.date.created | 2021-10-11 | - |
dc.date.created | 2021-10-11 | - |
dc.date.created | 2021-10-11 | - |
dc.date.issued | 2021-09 | - |
dc.identifier.citation | ACS BIOMATERIALS SCIENCE & ENGINEERING, v.7, no.9, pp.4318 - 4329 | - |
dc.identifier.issn | 2373-9878 | - |
dc.identifier.uri | http://hdl.handle.net/10203/288130 | - |
dc.description.abstract | fields due to their adhesive and cohesive properties, hemostatic abilities, and biocompatibility. Catechol moieties can be oxidized to o-catecholquinone, a chemically active intermediate, in the presence of oxygen to act as an electrophile to form catechol-catechol or catechol-amine/thiol adducts. To date, catechol cross-linking chemistry to fabricate hydrogels has been mostly performed at room temperature. Herein, we report large increases in catechol cross-linking reaction kinetics by the freeze-thawing process. The formation of ice crystals during freezing steps spatially condenses catechol-containing polymers into nearly frozen (yet unfrozen) regions, resulting in decreases in the polymeric chain distances. This environment allows great increases in catechol cross-linking kinetics, a phenomenon that can also occur during thawing steps. The increased cross-linking rate and spatial condensation in the cryogels provide unique wall and pore structures, which result in elastic, spongelike hydrogels. The moduli of the cryogels prepared by glycol-chitosan-catechol (g-chitosan-c) were improved by 3-6-fold compared to room temperature-cured conventional hydrogels, and the degree of improvement increased depending on the freezing time and the number of freeze-thawing cycles. Unlike typical cell encapsulations before cross-linking, which have often been a source of cytotoxicity, the macroporosity of cryogels allows nontoxic cell seeding with ease. This research offers a new way to utilize catechol cross-linking chemistry by freeze-thawing processes to simultaneously regulate mechanical strength and porous structures in catechol-containing hydrogels. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Freeze-Thawing-Induced Macroporous Catechol Hydrogels with Shape Recovery and Sponge-like Properties | - |
dc.type | Article | - |
dc.identifier.wosid | 000696370300017 | - |
dc.identifier.scopusid | 2-s2.0-85105031053 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 9 | - |
dc.citation.beginningpage | 4318 | - |
dc.citation.endingpage | 4329 | - |
dc.citation.publicationname | ACS BIOMATERIALS SCIENCE & ENGINEERING | - |
dc.identifier.doi | 10.1021/acsbiomaterials.0c01767 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, Haeshin | - |
dc.contributor.nonIdAuthor | Ryu, Ji Hyun | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | hydrogel | - |
dc.subject.keywordAuthor | cryogel | - |
dc.subject.keywordAuthor | glycol chitosan | - |
dc.subject.keywordAuthor | catechol | - |
dc.subject.keywordAuthor | porosity | - |
dc.subject.keywordPlus | CROSS-LINKING | - |
dc.subject.keywordPlus | POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | POLYMER SYSTEMS | - |
dc.subject.keywordPlus | CRYOGELS | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | ADHESIVE | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
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