DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choe, Kibaek | ko |
dc.contributor.author | Moon, Jieun | ko |
dc.contributor.author | Lee, Soo Yun | ko |
dc.contributor.author | Song, Eunjoo | ko |
dc.contributor.author | Back, Ju Hee | ko |
dc.contributor.author | Song, Joo-Hye | ko |
dc.contributor.author | Hyun, Young-Min | ko |
dc.contributor.author | Uchimura, Kenji | ko |
dc.contributor.author | Kim, Pilhan | ko |
dc.date.accessioned | 2021-09-26T01:50:27Z | - |
dc.date.available | 2021-09-26T01:50:27Z | - |
dc.date.created | 2021-09-24 | - |
dc.date.created | 2021-09-24 | - |
dc.date.created | 2021-09-24 | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | LIFE SCIENCE ALLIANCE, v.4, no.8 | - |
dc.identifier.issn | 2575-1077 | - |
dc.identifier.uri | http://hdl.handle.net/10203/287869 | - |
dc.description.abstract | High endothelial venules (HEVs) effectively recruit circulating lymphocytes from the blood to lymph nodes. HEVs have endothelial cells (ECs) and perivascular sheaths consisting of fibroblastic reticular cells (FRCS). Yet, post-luminal lymphocyte migration steps are not well elucidated. Herein, we performed intravital imaging to investigate post-luminal T- and B-cell migration in popliteal lymph node, consisting of trans-EC migration, crawling in the perivascular channel (a narrow space between ECs and FRCS) and trans-FRC migration. The post-luminal migration of T cells occurred in a PNAd-dependent manner. Remarkably, we found hot spots for the trans-EC and trans-FRC migration of T- and B cells. Interestingly, T- and B cells preferentially shared trans-FRC migration hot spots but not trans-EC migration hot spots. Furthermore, the trans-FRC T-cell migration was confined to fewer sites than trans-EC T-cell migration, and trans-FRC migration of T- and B cells preferentially occurred at FRCS covered by CD11c+ dendritic cells in HEVs. These results suggest that HEV ECs and FRCS with perivascular DCs delicately regulate T- and B-cell entry into peripheral lymph nodes. | - |
dc.language | English | - |
dc.publisher | LIFE SCIENCE ALLIANCE LLC | - |
dc.title | Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venules | - |
dc.type | Article | - |
dc.identifier.wosid | 000694804600005 | - |
dc.identifier.scopusid | 2-s2.0-85109662310 | - |
dc.type.rims | ART | - |
dc.citation.volume | 4 | - |
dc.citation.issue | 8 | - |
dc.citation.publicationname | LIFE SCIENCE ALLIANCE | - |
dc.identifier.doi | 10.26508/lsa.202101086 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Pilhan | - |
dc.contributor.nonIdAuthor | Lee, Soo Yun | - |
dc.contributor.nonIdAuthor | Back, Ju Hee | - |
dc.contributor.nonIdAuthor | Song, Joo-Hye | - |
dc.contributor.nonIdAuthor | Hyun, Young-Min | - |
dc.contributor.nonIdAuthor | Uchimura, Kenji | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | L-SELECTIN LIGANDS | - |
dc.subject.keywordPlus | FIBROBLASTIC RETICULAR CELLS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | LYMPH-NODES | - |
dc.subject.keywordPlus | TRANSENDOTHELIAL MIGRATION | - |
dc.subject.keywordPlus | BASAL LAMINA | - |
dc.subject.keywordPlus | O-GLYCANS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | TRAFFICKING | - |
dc.subject.keywordPlus | EXPRESSION | - |
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