Distinct impact of glycation towards the aggregation and toxicity of murine and human amyloid-beta
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Nam, Eunju | ko |
| dc.contributor.author | Han, Jiyeon | ko |
| dc.contributor.author | Choi, Sunhee | ko |
| dc.contributor.author | Lim, Mi Hee | ko |
| dc.date.accessioned | 2021-08-18T06:50:50Z | - |
| dc.date.available | 2021-08-18T06:50:50Z | - |
| dc.date.created | 2021-07-19 | - |
| dc.date.issued | 2021-08 | - |
| dc.identifier.citation | CHEMICAL COMMUNICATIONS, v.57, no.62, pp.7637 - 7640 | - |
| dc.identifier.issn | 1359-7345 | - |
| dc.identifier.uri | http://hdl.handle.net/10203/287221 | - |
| dc.description.abstract | Glycation of human A beta (hA beta) is implicated to induce the deposition of amyloid aggregates found in the Alzheimer's disease (AD)-affected brain. Murine A beta (mA beta) differs from hA beta in three different amino acid residues (Gly5, Phe10, and Arg13) and is less likely to form amyloid aggregates. Herein, we report that the advanced glycated end products of mA beta(40) over hA beta(40) are distinctly generated. The different glycation between the two peptides can govern their aggregation kinetics, structural transition, and cytotoxicity. | - |
| dc.language | English | - |
| dc.publisher | ROYAL SOC CHEMISTRY | - |
| dc.title | Distinct impact of glycation towards the aggregation and toxicity of murine and human amyloid-beta | - |
| dc.type | Article | - |
| dc.identifier.wosid | 000672419400001 | - |
| dc.identifier.scopusid | 2-s2.0-85111911843 | - |
| dc.type.rims | ART | - |
| dc.citation.volume | 57 | - |
| dc.citation.issue | 62 | - |
| dc.citation.beginningpage | 7637 | - |
| dc.citation.endingpage | 7640 | - |
| dc.citation.publicationname | CHEMICAL COMMUNICATIONS | - |
| dc.identifier.doi | 10.1039/d1cc02695j | - |
| dc.contributor.localauthor | Lim, Mi Hee | - |
| dc.contributor.nonIdAuthor | Choi, Sunhee | - |
| dc.description.isOpenAccess | N | - |
| dc.type.journalArticle | Article | - |
| dc.subject.keywordPlus | OXIDATIVE STRESS | - |
| dc.subject.keywordPlus | END-PRODUCTS | - |
| dc.subject.keywordPlus | PEPTIDE | - |
| dc.subject.keywordPlus | METHYLGLYOXAL | - |
| dc.subject.keywordPlus | INSIGHTS | - |
| dc.subject.keywordPlus | STATE | - |
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