DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, In-Ho | ko |
dc.contributor.author | Eun, Hyuk Soo | ko |
dc.contributor.author | Kim, Ja Kyung | ko |
dc.contributor.author | Lee, Hoyoung | ko |
dc.contributor.author | Jeong, Seongju | ko |
dc.contributor.author | Choi, Seong Jin | ko |
dc.contributor.author | Lee, Jeewon | ko |
dc.contributor.author | Lee, Byung Seok | ko |
dc.contributor.author | Kim, Seok Hyun | ko |
dc.contributor.author | Rou, Woo Sun | ko |
dc.contributor.author | Lee, Dong Hyeon | ko |
dc.contributor.author | Kim, Won | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2021-08-09T06:10:46Z | - |
dc.date.available | 2021-08-09T06:10:46Z | - |
dc.date.created | 2021-08-09 | - |
dc.date.created | 2021-08-09 | - |
dc.date.created | 2021-08-09 | - |
dc.date.issued | 2021-07 | - |
dc.identifier.citation | CELL REPORTS, v.36, no.4 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10203/287080 | - |
dc.description.abstract | During microbial infection, bystander CD8(+) T cells that are not specific to infecting pathogens can be activated by interleukin (IL)-15. However, the tissue-homing properties of bystander-activated CD8(+) T cells have not been elucidated. Here, we examine the effects of IL-15 on the expression of chemokine receptors on CD8(+) T cells and their migration. IL-15 upregulates CCR5 in memory CD8(+) T cells in the absence of T cell receptor (TCR) stimulation and enhances CCR5-dependent migration. IL-15-induced CCR5 upregulation is abrogated by TCR stimulation, indicating that CCR5 is upregulated in bystander-activated CD8(+) T cells. Moreover, CCR5 signals increase proliferation and cytotoxic protein expression in IL-15-treated memory CD8(+) T cells, although the increase has a small extent. CCR5 upregulation in bystander-activated CD8(+) T cells is associated with severe liver injury in patients with acute hepatitis A. Altogether, the results indicate that CCR5 upregulation by IL-15 mediates the migration of bystander-activated CD8(+) T cells. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | IL-15 enhances CCR5-mediated migration of memory CD8(+) T cells by upregulating CCR5 expression in the absence of TCR stimulation | - |
dc.type | Article | - |
dc.identifier.wosid | 000678096100001 | - |
dc.identifier.scopusid | 2-s2.0-85111217738 | - |
dc.type.rims | ART | - |
dc.citation.volume | 36 | - |
dc.citation.issue | 4 | - |
dc.citation.publicationname | CELL REPORTS | - |
dc.identifier.doi | 10.1016/j.celrep.2021.109438 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Eun, Hyuk Soo | - |
dc.contributor.nonIdAuthor | Kim, Ja Kyung | - |
dc.contributor.nonIdAuthor | Choi, Seong Jin | - |
dc.contributor.nonIdAuthor | Lee, Byung Seok | - |
dc.contributor.nonIdAuthor | Kim, Seok Hyun | - |
dc.contributor.nonIdAuthor | Rou, Woo Sun | - |
dc.contributor.nonIdAuthor | Lee, Dong Hyeon | - |
dc.contributor.nonIdAuthor | Kim, Won | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | INNATE-LIKE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | CHEMOKINES | - |
dc.subject.keywordPlus | EXPANSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | EBV | - |
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