Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19

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The upper respiratory tract is compromised in the early period of COVID-19, but SARS-CoV-2 tropism at the cellular level is not fully defined. Unlike recent single-cell RNA-Seq analyses indicating uniformly low mRNA expression of SARS-CoV-2 entry-related host molecules in all nasal epithelial cells, we show that the protein levels are relatively high and that their localizations are restricted to the apical side of multiciliated epithelial cells. In addition, we provide evidence in patients with COVID-19 that SARS-CoV-2 is massively detected and replicated within the multiciliated cells. We observed these findings during the early stage of COVID-19, when infected ciliated cells were rapidly replaced by differentiating precursor cells. Moreover, our analyses revealed that SARS-CoV-2 cellular tropism was restricted to the nasal ciliated versus oral squamous epithelium. These results imply that targeting ciliated cells of the nasal epithelium during the early stage of COVID-19 could be an ideal strategy to prevent SARS-CoV-2 propagation.
Publisher
AMER SOC CLINICAL INVESTIGATION INC
Issue Date
2021-07
Language
English
Article Type
Article
Citation

JOURNAL OF CLINICAL INVESTIGATION, v.131, no.13

ISSN
0021-9738
DOI
10.1172/JCI148517
URI
http://hdl.handle.net/10203/286974
Appears in Collection
MSE-Journal Papers(저널논문)
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