Pupil-aberration calibration with controlled illumination for quantitative phase imaging

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Quantitative phase imaging (QPI) exploits sample-induced changes in the optical field to analyze biological specimens in a label-free manner. However, the quantitative nature of QPI makes it susceptible to optical aberrations. We propose a method for calibrating pupil aberrations by imaging a sample of interest. The proposed method recovers pupil information by utilizing the cross-spectral density between optical fields at different incident angles and allows both thin and weakly scattering three-dimensional samples for calibration. We experimentally validate the proposed method by imaging various samples, including a resolution target, breast tissue, and a polystyrene bead, and demonstrate aberration-free two- and three-dimensional QPI. 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Publisher
OPTICAL SOCIETY AMERICA
Issue Date
2021-07
Language
English
Article Type
Article
Citation

OPTICS EXPRESS, v.29, no.14, pp.22127 - 22135

ISSN
1094-4087
DOI
10.1364/OE.426080
URI
http://hdl.handle.net/10203/286774
Appears in Collection
PH-Journal Papers(저널논문)
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