Chitosan-based blends for biomedical applications

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Polysaccharides are the most abundant naturally available carbohydrate polymers; composed of monosaccharide units covalently connected together. Chitosan is the most widely used polysaccharides because of its exceptional biocompatibility, mucoadhesion, and chemical versatility. However, it suffers from a few drawbacks, e.g. poor mechanical properties and antibacterial activity for biomedical applications. Blending chitosan with natural or synthetic polymers may not merely improve its physicochemical and mechanical properties, but may also improve its bioactivity-induced properties. This review paper summarizes progress in chitosan blends with biodegradable polymers and polysaccharides and their biomedical applications. Blends of chitosan with alginate, starch, cellulose, pectin and dextran and their applications were particularly addressed. The critical and challenging aspects as well as the future ahead of the use of chitosan-based blends were eventually enlightened. (c) 2021 Published by Elsevier B.V.
Publisher
ELSEVIER
Issue Date
2021-07
Language
English
Article Type
Review
Citation

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.183, pp.1818 - 1850

ISSN
0141-8130
DOI
10.1016/j.ijbiomac.2021.05.003
URI
http://hdl.handle.net/10203/286732
Appears in Collection
RIMS Journal Papers
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