A hysteretic moment-curvature relation for analyzing reinforced concrete (RC) members subjected to blast loading is introduced in this paper. After constructing a monotonic envelope curve for the moment-curvature relation, the hysteretic behaviors of unloading and reloading are defined based on the hysteretic curve of steel. The use of the moment-curvature relation in the blast analysis becomes possible by introducing a dynamic increase factor (DIF), which is defined in terms of the curvature rate. This makes it possible to analyze RC structures composed of many bending structural members. In addition to defining a basic hysteretic moment-curvature relation, additional influencing factors such as the bond-slip effect and direct shear behavior, which are expected to affect the structural responses, are taken into consideration for an exact simulation of the nonlinear dynamic response of RC flexural members. The validity of the introduced hysteretic moment-curvature relation is established by correlation studies between the analytical results and experimental data experiencing repeated unloading and reloading phases. The obtained numerical results also show the importance of the bond-slip effect and the hysteretic behavior on the structural response of RC flexural members subjected to blast loading.