Molecular laterality encodes stress susceptibility in the medial prefrontal cortex

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dc.contributor.authorChae, Sujinko
dc.contributor.authorHong, Jisoko
dc.contributor.authorKang, Keunsooko
dc.contributor.authorShin, Annako
dc.contributor.authorKim, Dae-Gunko
dc.contributor.authorLee, Sinjeongko
dc.contributor.authorKim, Moo-youngko
dc.contributor.authorJung, Inkyungko
dc.contributor.authorKim, Daesooko
dc.date.accessioned2021-06-30T01:10:57Z-
dc.date.available2021-06-30T01:10:57Z-
dc.date.created2021-06-30-
dc.date.created2021-06-30-
dc.date.issued2021-06-
dc.identifier.citationMOLECULAR BRAIN, v.14, no.1-
dc.identifier.issn1756-6606-
dc.identifier.urihttp://hdl.handle.net/10203/286286-
dc.description.abstractFunctional lateralization of the prefrontal cortex has been implicated in stress and emotional disorders, yet underlying gene expression changes remains unknown. Here, we report molecular signatures lateralized by chronic social defeats between the two medial prefrontal cortices (mPFCs). Stressed mice show 526 asymmetrically expressed genes between the mPFCs. This cortical asymmetry selectively occurs in stressed mice with depressed social activity, but not in resilient mice with normal behavior. We have isolated highly asymmetric genes including connective tissue growth factor (CTGF), a molecule that modulates wound healing at the periphery. Knockdown of CTGF gene in the right mPFC by shRNA led to a stress-resistant behavioral phenotype. Overexpression of CTGF in the right mPFC using viral transduction induces social avoidance while the left mPFC thereof prevent stress-induced social avoidance. Our study provides a molecular window into the mechanism of stress-induced socioemotional disorders, which can pave the way for new interventions by targeting cortical asymmetry.-
dc.languageEnglish-
dc.publisherBMC-
dc.titleMolecular laterality encodes stress susceptibility in the medial prefrontal cortex-
dc.typeArticle-
dc.identifier.wosid000661491500001-
dc.identifier.scopusid2-s2.0-85107895997-
dc.type.rimsART-
dc.citation.volume14-
dc.citation.issue1-
dc.citation.publicationnameMOLECULAR BRAIN-
dc.identifier.doi10.1186/s13041-021-00802-w-
dc.contributor.localauthorJung, Inkyung-
dc.contributor.localauthorKim, Daesoo-
dc.description.isOpenAccessY-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorMolecular laterality-
dc.subject.keywordAuthorSocial defeat stress-
dc.subject.keywordAuthorConnective tissue growth factor (CTGF)-
dc.subject.keywordAuthorMedial prefrontal cortex-
dc.subject.keywordAuthorDepression-
dc.subject.keywordPlusSOCIAL DEFEAT STRESS-
dc.subject.keywordPlusTISSUE GROWTH-FACTOR-
dc.subject.keywordPlusTRANSCRANIAL MAGNETIC STIMULATION-
dc.subject.keywordPlusFRONTAL EEG ASYMMETRY-
dc.subject.keywordPlusDECISION-MAKING-
dc.subject.keywordPlusSEX-DIFFERENCES-
dc.subject.keywordPlusLEFT BRAIN-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusRESILIENT-
dc.subject.keywordPlusDEPRESSION-
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