DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Noori | ko |
dc.contributor.author | Han, Kyungsup | ko |
dc.contributor.author | Su, Pei-Chen | ko |
dc.contributor.author | Kim, Insup | ko |
dc.contributor.author | Yoon, Yong-Jin | ko |
dc.date.accessioned | 2021-06-21T06:50:21Z | - |
dc.date.available | 2021-06-21T06:50:21Z | - |
dc.date.created | 2021-06-21 | - |
dc.date.created | 2021-06-21 | - |
dc.date.created | 2021-06-21 | - |
dc.date.issued | 2021-04 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.11, no.1 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/286022 | - |
dc.description.abstract | Label-free optical biosensors have received tremendous attention in point-of-care testing, especially in the emerging pandemic, COVID-19, since they advance toward early-detection, rapid, real-time, ease-of-use, and low-cost paradigms. Protein biomarkers testings require less sample modification process compared to nucleic-acid biomarkers'. However, challenges always are in detecting low-concentration for early-stage diagnosis. Here we present a Rotationally Focused Flow (RFF) method to enhance sensitivity(wavelength shift) of label-free optical sensors by increasing the detection probability of protein-based molecules. The RFF is structured by adding a less-dense fluid to focus the target-fluid in a T-shaped microchannel. It is integrated with label-free silicon microring resonators interacting with biotin-streptavidin. The suggested mechanism has demonstrated 0.19 fM concentration detection along with a significant magnitudes sensitivity enhancement compared to single flow methods. Verified by both CFD simulations and fluorescent flow-experiments, this study provides a promising proof-of-concept platform for next-generation lab-on-a-chip bioanalytics such as ultrafast and early-detection of COVID-19. | - |
dc.language | English | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | A rotationally focused flow (RFF) microfluidic biosensor by density difference for early-stage detectable diagnosis | - |
dc.type | Article | - |
dc.identifier.wosid | 000656206800006 | - |
dc.identifier.scopusid | 2-s2.0-85105179424 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/s41598-021-88647-0 | - |
dc.contributor.localauthor | Yoon, Yong-Jin | - |
dc.contributor.nonIdAuthor | Kim, Noori | - |
dc.contributor.nonIdAuthor | Han, Kyungsup | - |
dc.contributor.nonIdAuthor | Su, Pei-Chen | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | LABEL-FREE | - |
dc.subject.keywordPlus | MICRORING RESONATOR | - |
dc.subject.keywordPlus | OPTICAL BIOSENSORS | - |
dc.subject.keywordPlus | STREPTAVIDIN | - |
dc.subject.keywordPlus | BIOMOLECULES | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordPlus | FIELD | - |
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