Enantioselective Access to Spirolactams via Nitrenoid Transfer Enabled by Enhanced Noncovalent Interactions

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Described herein is the Ir-catalyzed enantioselective access to chiral spirolactam products via the nitrenoid transfer to aromatic ipso-carbons. The key strategy for precise stereocontrol is to enhance the secondary attractive and repulsive interactions between the chiral catalyst and substrates by the introduction of a traceless O-silyl achiral auxiliary, thus effectively differentiating two prochiral faces of arenol-derived 1,4,2-dioxazol-5-one substrates.
Publisher
AMER CHEMICAL SOC
Issue Date
2021-05
Language
English
Article Type
Article
Citation

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.143, no.17, pp.6363 - 6369

ISSN
0002-7863
DOI
10.1021/jacs.1c02550
URI
http://hdl.handle.net/10203/285306
Appears in Collection
CH-Journal Papers(저널논문)
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