Comparative analysis of hermaphrodite and male caenorhabditis elegans connectomes based on complex network theory = 복잡계 네트워크 분석법을 이용한 예쁜꼬마선충 수컷과 자웅동체의 커넥톰 비교

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 16
  • Download : 0
C. elegans are nematodes that exist in two sexes: hermaphrodite and male. Although these two sexes share a lot of structurally similar neurons, their nervous system is strongly sexualized and functionality differs at multiple levels. For decades, hermaphrodite c. elegans has been the only organism with a complete cellular level connectome. Recently, a complete neural wiring has been constructed for male c. elegans as well. Network analysis of an organism’s neural wiring reveals the role of connection topology in the nervous system’s structure and function. In this work, we analyzed connectomes of the two sexes of c. elegans using graph theoretical tools and community detection methods to understand network level differences in their nervous system. Both networks are small-world and display heavy tailed degree distributions. However, the hermaphrodite neurons tend to have more diverse connections than male, whereas the male neurons form stronger connections with each other. In addition, the hermaphrodite connectome is disassortative while the male connectome shows positive assortativity. Clustering coefficient analysis reveals that the hermaphrodite connectome shows hierarchical organization while the male connectome does not. Both connectomes show rich club organization, however neurons that form the rich clubs are not the same for the two sexes. Both connectomes show modular structure with sex-specific neurons interacting with sex-shared neurons in separate communities. We also tested and found sex-shared, but quantitatively dimorphic neurons using various nodal features.
Advisors
Jeong, Jaeseungresearcher정재승researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2020.8,[iii, 55 p. :]

Keywords

예쁜꼬마선충▼a커넥톰▼a복잡한 네트워크▼a네트워크 특성▼a이형성 뉴런▼a공동체의 발견; C. elegans▼aconnectome▼acomplex network▼anetwork features▼adimorphic neurons▼acommunity detection

URI
http://hdl.handle.net/10203/284936
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=925095&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0