Anti-CD47 antibody STING agonist conjugate for activating macrophage-mediated cancer immunotherapy in tumor microenvironment = 종양미세환경 내 대식세포의 항암면역작용 활성화를 위한 CD47 항체-STING 작용제 복합체 개발

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For successful cancer immunotherapy, immuno-suppressive tumor microenvironment must be overcome. Tumor-associated macrophages have emerged as one of the attractive targets of cancer immunotherapy due to their key role in contributing to immune suppression. Although studies have been successfully targeting the CD47 protein that are overexpressed on cancers and inhibits phagocytosis of macrophages, there are limitations that it is difficult to induce adaptive immune responses. In this dissertation, to maximize the anti-tumor immune function of macrophages, synergistic effects of anti-CD47 antibody to enhance the phagocytosis and STING agonist that promote the antigen presentation of engulfing macrophages, mediate adaptive immune responses were observed. Finally, anti-CD47 antibody STING agonist conjugate was developed and the effect of activating anti-cancer immune function of macrophages were evaluated.
Advisors
Park, Ji-Horesearcher박지호researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2020.8,[v, 45 p. :]

Keywords

Cancer immunotherapy▼aTumor microenvironment▼aMacrophage▼aAnti-CD47 antibody▼aSTING agonist; 항암면역치료▼a종양미세환경▼a대식세포▼aCD47 항체▼aSTING 작용제

URI
http://hdl.handle.net/10203/284934
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=925093&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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