Spread spectrum surface plasmon resonance sensor for ultrasensitive detection of E.coli O157:H7 using dual LED excitation = 초 민감 대장균 검출을 위한 이중 발광 다이오드 기반 확산 스펙트럼 표면 플라즈몬 공명 센서

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Water quality monitoring is the primary control point in the prevention of disease caused by pathogens Especially, Escherichia Coli (E.coli) is known as fecal indicator bacteria. E.coli detection is important because water quality can be easily determined. However, Conventional water monitoring methods to detect E.coli are time consuming and laboratory-based assay. Therefore, simple and fast detection method is needed. Surface plasmon resonance (SPR) are getting attention in optical bio-sensing applications because it has many advantages that label free, without various agents, minimal amount sample and real-time monitoring. The most widespread mode of SPR sensor is Kretschmann geometry. This configuration is bulky and has limitation for increasing resolution due to various noises. We proposed compact spread spectrum SPR (ss-SPR) sensor with high signal-to-noise-ratio (SNR) using dual wavelengths LED appling spread spectrum technique. The compact ss-SPR sensor was designed to be 27mm width and 37mm height size. Standard deviation measured by spread spectrum technique was 35 percentage decreased and SNR was increased about 100 times than continuous wave (CW) measurement. And limit of detection (LOD) of e.coli was $2.24 \times 10^2cfu/ml$, which is an improvement over the result of CW measurement. The proposed compact ss-SPR sensor will be applied for low concentration target molecule detection.
Advisors
Jeong, Ki-Hunresearcher정기훈researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2020.8,[x, 62 p. :]

Keywords

Surface plasmon resonance sensor▼acompact▼aspread spectrum technique▼aE.coli▼aLimit of detection; 표면 플라즈몬 공명 센서▼a소형▼a화산 스팩트럼 기술▼a대장균▼a검출한계

URI
http://hdl.handle.net/10203/284927
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=925086&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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