Isolation and characterization of a novel antimicrobial peptide from Bufo bufo gargarizans = 한국산 두꺼비로부터 새로운 항균 펩타이드 분리와 그 특성 연구

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A novel antimicrobial peptide was isolated from Bufo bufo gargarizans, an Asian toad, using heparin chromatography and reversed-phase HPLC. The antimicrobial peptide killed Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas putida, Salmonella typhimurium, Candida albicans. The complete amino acid sequence of the antimicrobial peptide was, Ala-Gly-Arg-Gly-Lys-Gln-Gly-Gly-Lys-Val-Arg-Ala-Lys-Ala-Lys-Thr-Arg-Ser-Ser- Arg-Ala-Gly-Leu-Gln-Phe-Pro-Val-Gly-Arg-Val-His-His-Leu-Leu-Leu-Leu-Lys-Gly- Asn-Tyr. The peptide has no homology with other known antimicrobial peptides except the human histone H2A protein to which the antimicrobial peptide is identical in 35 of 40 amino-terminal residues. We believe that this is a new antimicrobial peptide which does not belong to any other known classes of antimicrobial peptides.
Advisors
Kim, Sun-Chang김성찬
Description
한국과학기술원 : 생물공학과,
Publisher
한국과학기술원
Issue Date
1995
Identifier
98702/325007 / 000933218
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생물공학과, 1995, [ v, 35 p. ]

Keywords

단백질 분리

URI
http://hdl.handle.net/10203/28468
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=98702&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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