DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Lee, Wonhee | - |
dc.contributor.advisor | 이원희 | - |
dc.contributor.author | Kim, Jeong-ah | - |
dc.date.accessioned | 2021-05-12T19:47:15Z | - |
dc.date.available | 2021-05-12T19:47:15Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=947922&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/284544 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 물리학과, 2019.2,[ⅹ, 115 p. :] | - |
dc.description.abstract | The advantages of microfluidics include reducing expense with smaller reagents, inducing faster reactions, and precisely controlling samples with small sizes. Therefore, it has been extensively studied in biological, chemical and medical systems. Characteristics of fluids can be divided into different regions of Reynolds numbers. In Stokes flow (Re<1), flowing particles simply follow the streamlines. In the intermediate Re (~1 < Re < ~100) between Stokes and turbulent regimes, particles are affected by inertial lift forces and migrate across the streamlines. Then, particles are focused into equilibrium positions (or focusing positions). This phenomenon is called inertial focusing. Using inertial focusing, the location of particles can be manipulated within the microchannel without external forces.The number and configuration of focusing positions are affected by the channel structures. In this dissertation, we fabricated various microchannels using MEMS and investigated the relation between fluidic phenomena and channel structures. First, we elucidated the basics of inertial microfluidics in Chapter 1. In chapter 2, we investigated inertial focusing in non-rectangular cross-section channels (half-circle, triangle) and suggested the method for particle manipulation using various cross-section shapes. In chapter 3, we explained the change of focusing positions in triangular channel depending on particle size and Re, and presented the channels for size-based separation. In chapter 4, we observed the tendency of inertial focusing in accordance with particle size, Re and angles. In chapter 5, we presented the 3D curved triangular channels consisted with thin PDMS film with high flexibility. Then, we investigated the alteration of stable focusing positions by Dean flow formation and validated that curved triangular channel can be applied to both sheath-less flow cytometry and rare cell separation. In chapter 6, we suggested the novelty of research and future prospective of inertial microfluidics. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Microfluidics▼aInertial microfluidic▼aInertial focusing▼aNon-rectangular microchannel▼aTriangular microchannel▼a3D curved channel▼aParticle manipulation | - |
dc.subject | 미세유체▼a관성미세유체▼a관성집중▼a비직사각형 미세채널▼a삼각형 미세채널▼a3D 곡면 채널▼a입자조작기술 | - |
dc.title | Inertial focusing and microparticle separations in triangular cross-section microchannels | - |
dc.title.alternative | 삼각형 단면 미세채널에서 관성집중 및 미세입자 분리 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :물리학과, | - |
dc.contributor.alternativeauthor | 김정아 | - |
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