DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Eunjoon | - |
dc.contributor.advisor | 김은준 | - |
dc.contributor.author | Kim, Kyungdeok | - |
dc.date.accessioned | 2021-05-12T19:45:12Z | - |
dc.date.available | 2021-05-12T19:45:12Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=924492&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/284427 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2020.8,[iii, 95 p. :] | - |
dc.description.abstract | Cell Adhesion Molecule) initiates synapse formation via interacting with specific binding partners. However, functions of CAM during maintenance period and plasticity are shortly investigated. Here, I discovered an important presynaptic hub CAM, PTP$\sigma$, stabilizes NMDA-R in hippocampal SC-CA1 synapses by trans-synaptic manner, without affecting synapse formation. Surprisingly, this NMDA-R regulation works through intracellular domains and phosphatase activity of PTP$\sigma$, rather than famous extracellular bindings known to mediating synapse formation. Lacking PTP$\sigma$ causes broad range of phosphor-tyrosine level changes across the synaptic cleft, and one/many of those substrates is highly probable to mediate NMDA-R function regulation. In behavioral-wide, aberrant NMDA-R function in SC-CA1 by presynaptic KO of PTP$\sigma$, as well as postsynaptic KD of essential subunit of NMDA-R, causes impairment of novelty recognition. | - |
dc.description.abstract | CAM ( | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Synapse▼aPTP$\sigma$▼aNMDA-R▼aCAM▼aphosphatase▼anovelty recognition | - |
dc.subject | 시냅스▼aPTP$\sigma$▼aNMDA 수용체▼a세포 접착 단백질▼a탈인산화 효소▼a새로움 인지 | - |
dc.title | Circuit-specific regulation of synapse formation by the protein tyrosine phosphatase PTP$\sigma$ | - |
dc.title.alternative | 타이로신 탈인산화 효소 수용체 PTP$\sigma$에 의한 시냅스 기능 조절 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
dc.contributor.alternativeauthor | 김경덕 | - |
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