(The) antimutagenic effect of sodium selenite against benzo(a)phrene in CHO cells and salmonella typhimurium = CHO 세포와 salmonella typhimurium에서 benzo(a)pyrene에 대한 sodium selenite의 항돌연변이성에 관한 연구

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 977
  • Download : 0
Benzo(a)pyrene was observed to be mutagenic only in the presence of S9 fraction in S. typhimurium TA98. The number of His$^+$ revertants increased in proportion to the level of B(a)P. The lethality showed up over $10 \mu g/plate$. Sodium selenite was not mutagenic in the range of 0-10 g/plate, nor activated by S9 fraction. It supports selenium``s promptness in suppressing the mutation by a large part. On the contrary to B(a)P``s cytotoxic effect and inhibition of cell growth as well as its mutagenicity, selenite was observed to promote the cell growth with very little mutagenic effect. Moreover, selenite of growth promoting concentrations($\sim{6\times{10^{-8}}$M) significantly reduced the incidences of mutation (to about 50\%) induced with B(a)P 0.5 g/ml. This result suggests selenium``s ability of suppressing mutation is not attributable to only its growth inhibition of tumor cells. This study clarified that selenium of nonmutagenic level($\sim 6\times{10^{-8}}$M)could able to prevent carcinogenesis at the early initiation phase.
Advisors
Chung, An-Sik정안식
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
1994
Identifier
69122/325007 / 000923159
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 1994.2, [ vi, 42 p. ]

URI
http://hdl.handle.net/10203/28415
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=69122&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0