Study on combination of polydopamine and gold nanorods for photothermal neuronal activity modulation platform = 폴리도파민과 금나노막대를 결합한 광열 신경 활동 조절 플랫폼에 대한 연구

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Polydopamine is a multifunctional adhesive polymer, which is applicable to the surface modification for neural interface. The polymer is widely used in the biomedical field as a primer layer for immobilizing materials having amine or thiol groups on their surfaces. In addition, polydopamine is a potential candidate for photothermal treatment of cancer, due to its wide absorption spectra and photothermal effects with the NIR region of light. In this paper, the optical and photothermal properties of polydopamine film, and the attachment of gold nanorods on the polydopamine film were investigated, in efforts to apply the adhesive and photothermal properties of polydopamine to the photothermal nerve stimulation platform. Finally, in order to evaluate the function and efficiency of the combination of polydopamine and gold nanorods in neuronal activity inhibition, cultured neurons were photostimulated. This study suggested the feasibility of using polydopamine as a surface modification material for developing photothermal platform for inhibition of neural activities in vitro.
Advisors
Nam, Yoonkeyresearcher남윤기researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2020.2,[vii, 88 p. :]

Keywords

Polydopamine▼aPhotothermal effects▼aSurface modification▼aGold nanorods▼aNeural activity modulation; 폴리도파민▼a금나노막대▼a광열효과▼a표면처리▼a신경세포 활동 제어

URI
http://hdl.handle.net/10203/283843
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=909924&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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