Application of feedback system to photothermal neural suppression technique for spike-rate control = 뉴런의 발화율 조절을 위한 피드백 시스템의 광열 신경 억제 기술에의 적용

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Recently, photothermal stimulation has emerged as a technology that can regulate neuronal activity at high space-time resolution without the need for genetic modification. The focus is on finding ways to safely control neuronal activity to specific values using photothermal stimulation mediated with gold nanorods (GNRs). To achieve this, we created a real-time feedback system that reads the spike-rate of neurons in real time and automatically adjusts the power of the laser, on the three steps. First, we defined the limit of the laser power for the system to avoid thermal damage to neurons. Second, to implement a real-time closed loop system with a microcontroller and verify its operation, a system for controlling temperature by irradiating NIR light on a surface coated with gold nanoparticles was created. Third, we built a feedback system that reads the number of neuronal spikes in real time and automatically adjusts the light intensity accordingly. The system was applied to live neurons to control the target spike rate for 5 minutes and showed an RMS error of less than 0.5 Hz in all experiments. This technique could be applied to brain therapy, to neuroscience, or to brain-computer interfaces.
Advisors
Nam, Yoonkeyresearcher남윤기researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2020.2,[xii, 113 p. :]

Keywords

Real-time feedback▼aClosed-loop▼aphotothermal stimulation▼aPhotothermal suppression▼aMEA▼aGold nanorods; 실시간 피드백▼a폐루프 시스템▼a광열 자극▼a광열 억제▼aMEA▼a금나노입자

URI
http://hdl.handle.net/10203/283838
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=909919&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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