Gene essentiality for tumor growth influences neoantigen-directed immunoediting = 유전자의 암 생장 필수성이 신생항원 매개 면역 회피 현상에 미치는 영향 연구

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Neoantigens arisen from mutated proteins in cancer cells are cancer-specific and can be highly immunogenic. However, outgrowth of tumor clones down-regulating their antigens can evade from immune responses. Here, I defined constitutive neoantigen and facultative neoantigen according to the essentiality of neoantigen-expressing genes for tumor growth based on functional screening and single-cell transcriptome data. Our own and public cohort data revealed the influence of the gene-level properties on clinical responses to immune checkpoint inhibitor. The pre-therapy constitutive neoantigen load and on-therapy down-regulation of the constitutive neoantigens contributed to positive clinical responses. In contrast, patients with negative clinical responses showed expansion of tumor clones down-regulating facultative neoantigens, implying immunoediting. Therefore, immunoediting may possibly be minimized by steering anti-tumor immune responses toward neoantigens expressed from essential genes.
Advisors
Choi, Jung Kyoonresearcher최정균researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2020.2,[iii, 52 p. :]

Keywords

neoantigen▼agene essentiality▼aimmune checkpoint inhibitor▼aimmunoediting▼atumor; 신생항원▼a유전자 필수성▼a면역관문억제제▼a면역 회피▼a암

URI
http://hdl.handle.net/10203/283835
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=909916&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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