Shear-induced structures of microtubules = 전단력에 의한 마이크로튜불의 구조 연구

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Microtubules (MTs), one of the major components of eukaryotic cytoskeleton, are hollow 25 nm diameter proteinnanotubes involved in numerous cellular functions including intracellular trafficking, cell division, and cell shaping. In biological systems, MTs are subjected to shear stress caused by traumatic brain injury (TBI), blood flow, and cytoplasmic streaming. While MTs are reported to be involved in the generation of cytoplasmic flow and the morphological changes of the endothelial cells in response to blood flow, the exact structural behaviors of MTs under shear stress still remain to be elucidated. In this study, the shear-induced alignment, breakage, polymerization, and buckling of MTs are identified by using rotational rheometer and synchrotron small angle X-ray scattering(SAXS). The findings may provide insight into the structural mechanisms of MTs in biological systems, and can be applied for nanostructure engineering.
Advisors
Choi, Myung Chulresearcher최명철researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2020.2,[iii, 42 p. :]

Keywords

Microtubules▼aShear stress▼aRotational rheometer▼aSmall angle X-ray scattering▼aNanostructure; 마이크로튜불▼a전단력▼a회전형 유동계▼a소각 엑스선 산란▼a나노구조

URI
http://hdl.handle.net/10203/283834
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=909915&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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