Developing an integrated eQTL database for psychiatric disorder analysis = 정신질환 분석을 위한 통합된 eQTL 데이터베이스의 개발

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eQTL analysis has been popular to find genetic etiology of psychiatric disorders. However, there is no integrated database which harbors linkage between eQTL gene and psychiatric disorders to show possible connections between them. In this research, we analyzed eQTL associations from the Stanley Medical Research Institute (SMRI) brain genomics data and integrated them with psychiatric disorder GWAS associations. As a result, we have calculated 316,319 eQTL associations from four tissues in gene and transcript level and developed an integrated database with gene-disorder network analysis results. With the database, users can get integrated information about enlisted entities with associations between them and get possible integrated insight towards genetic etiology of psychiatric disorders.
Advisors
Lee, Doheonresearcher이도헌researcher
Description
한국과학기술원 :바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2020
Identifier
325007
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2020.2,[iv, 50 p. :]

Keywords

eQTL association▼aGWAS▼apsychiatric disorder▼anetwork analysis▼adatabase; eQTL 연관관계▼a전장 유전체 연관 분석▼a정신질환▼a네트워크 분석▼a데이터베이스

URI
http://hdl.handle.net/10203/283831
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=909912&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
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