DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Park, Chan-Kyu | - |
dc.contributor.advisor | Yang, Kyu-Hwan | - |
dc.contributor.advisor | 박찬규 | - |
dc.contributor.advisor | 양규환 | - |
dc.contributor.author | Eo, Seong-Kug | - |
dc.contributor.author | 어성국 | - |
dc.date.accessioned | 2011-12-12T08:59:01Z | - |
dc.date.available | 2011-12-12T08:59:01Z | - |
dc.date.issued | 1990 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=67708&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/28371 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생물공학과, 1990, [ [iv], 56 p. ] | - |
dc.description.abstract | To study the induction of drug metabolism associated to cytochrome P-450 by alpha-naphthoflavone(ANF), we determined specific cytochrome P-450 dependent monooxygenase activities according to culture time and dose of ANF by using specific substrate to each cytochrome P-450, especially phenobarbital(PB)- and 3-methylcholanthrene(MC)-inducible type of P-450, and compared with activity of in two media. We found that the activity of cytochrome P-450 dependent drug metabolism was increased by the addition of ANF to culture medium. This induction of cytochrome P-450 was also idemtified by the quantitation of P-450 mRNA using typespecific oligonucleotide probe in hybridization. Also we detected the inhibition of TCDD-mediated P-450 induction by ANF(10 uM) to examine whether the induction of cytochrome P-450 by ANF occur through the cytosolic Ah receptor. In conclusion, it seems that the induction of cytochrome P-450 by ANF may be occur by the accumulation of mRNA through receptor-ligand level. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Induction of cytochrome P-450S by alpha-naphthoflavone in primary cultures of adult rat hepatocytes | - |
dc.title.alternative | Alpha-naphthoflavone 에 의한 일차 배양 간세포의 cytochrome P-450 유도 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 67708/325007 | - |
dc.description.department | 한국과학기술원 : 생물공학과, | - |
dc.identifier.uid | 000891275 | - |
dc.contributor.localauthor | Park, Chan-Kyu | - |
dc.contributor.localauthor | Yang, Kyu-Hwan | - |
dc.contributor.localauthor | 박찬규 | - |
dc.contributor.localauthor | 양규환 | - |
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