Processing of mouse gastrin mRNA at 3' flanking region = 생쥐의 가스트린 mRNA에 있어서 3' 쪽의 poly(A) 부착에 대한 분석

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In mouse, the antrum is the major site of gastrin expression. Duodenum also express gastrin, but the level of expression is low. Mouse gastrin mRNA has AAUAAG sequence as a putative polyadenylation signal rather than AAUAAA. Thus the gastrin expression level of mouse is lower than that of rat. Although the cleavage efficiency is relatively low, once they have been cleaved even with AAUAAG sequence, they are polyadenylated as efficiently as with AAUAAA. In the tissue, unprocessed RNA transcripts are rapidly degraded. Only processed RNAs are transported to cytoplasm. The duplicated CAUGU and GGAGAGGGGUUG, homologous to CAYUG and GT-rich sequence, are located at 25 and 43 nucleotides downstream from AAUAAG sequence. These sequence may function as downstream poly(A) addition signals. Thus mouse gastrin mRNA in the antral and duodenal tissue are normally processed, although the efficiency of processing is relatively lower than other mammalian species possessing AAUAAA as poly(A) addition signal.
Advisors
Yoo, Ook-Joonresearcher유욱준researcher
Description
한국과학기술원 : 생물공학과,
Publisher
한국과학기술원
Issue Date
1990
Identifier
67706/325007 / 000891131
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생물공학과, 1990, [ iv, 57 p. ]

URI
http://hdl.handle.net/10203/28369
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=67706&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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