Control of endothelial quiescence by FOXO-regulated metabolites

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dc.contributor.authorAndrade, Jorgeko
dc.contributor.authorShi, Chenyueko
dc.contributor.authorCosta, Ana S. H.ko
dc.contributor.authorChoi, Jeongwoonko
dc.contributor.authorKim, Jaeryungko
dc.contributor.authorDoddaballapur, Anuradhako
dc.contributor.authorSugino, Toshiyako
dc.contributor.authorOng, Yu Tingko
dc.contributor.authorCastro, Marcoko
dc.contributor.authorZimmermann, Barbarako
dc.contributor.authorKaulich, Manuelko
dc.contributor.authorGuenther, Stefanko
dc.contributor.authorWilhelm, Kerstinko
dc.contributor.authorKubota, Yoshiakiko
dc.contributor.authorBraun, Thomasko
dc.contributor.authorKoh, Gou Youngko
dc.contributor.authorGrosso, Ana Ritako
dc.contributor.authorFrezza, Christianko
dc.contributor.authorPotente, Michaelko
dc.identifier.citationNATURE CELL BIOLOGY, v.23, no.4, pp.413 - U210-
dc.description.abstractAndrade et al. show that FOXO1 regulates mitochondrial metabolism to stimulate the production of the metabolite S-2HG to promote acquisition of a quiescent endothelial state. Endothelial cells (ECs) adapt their metabolism to enable the growth of new blood vessels, but little is known how ECs regulate metabolism to adopt a quiescent state. Here, we show that the metabolite S-2-hydroxyglutarate (S-2HG) plays a crucial role in the regulation of endothelial quiescence. We find that S-2HG is produced in ECs after activation of the transcription factor forkhead box O1 (FOXO1), where it limits cell cycle progression, metabolic activity and vascular expansion. FOXO1 stimulates S-2HG production by inhibiting the mitochondrial enzyme 2-oxoglutarate dehydrogenase. This inhibition relies on branched-chain amino acid catabolites such as 3-methyl-2-oxovalerate, which increase in ECs with activated FOXO1. Treatment of ECs with 3-methyl-2-oxovalerate elicits S-2HG production and suppresses proliferation, causing vascular rarefaction in mice. Our findings identify a metabolic programme that promotes the acquisition of a quiescent endothelial state and highlight the role of metabolites as signalling molecules in the endothelium.-
dc.publisherNATURE RESEARCH-
dc.titleControl of endothelial quiescence by FOXO-regulated metabolites-
dc.citation.publicationnameNATURE CELL BIOLOGY-
dc.contributor.localauthorKoh, Gou Young-
dc.contributor.nonIdAuthorAndrade, Jorge-
dc.contributor.nonIdAuthorShi, Chenyue-
dc.contributor.nonIdAuthorCosta, Ana S. H.-
dc.contributor.nonIdAuthorKim, Jaeryung-
dc.contributor.nonIdAuthorDoddaballapur, Anuradha-
dc.contributor.nonIdAuthorSugino, Toshiya-
dc.contributor.nonIdAuthorOng, Yu Ting-
dc.contributor.nonIdAuthorCastro, Marco-
dc.contributor.nonIdAuthorZimmermann, Barbara-
dc.contributor.nonIdAuthorKaulich, Manuel-
dc.contributor.nonIdAuthorGuenther, Stefan-
dc.contributor.nonIdAuthorWilhelm, Kerstin-
dc.contributor.nonIdAuthorKubota, Yoshiaki-
dc.contributor.nonIdAuthorBraun, Thomas-
dc.contributor.nonIdAuthorGrosso, Ana Rita-
dc.contributor.nonIdAuthorFrezza, Christian-
dc.contributor.nonIdAuthorPotente, Michael-
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