DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Hail | - |
dc.contributor.advisor | 김하일 | - |
dc.contributor.author | Choi, Wonsuk | - |
dc.date.accessioned | 2021-05-11T19:43:37Z | - |
dc.date.available | 2021-05-11T19:43:37Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=907110&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/283573 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학대학원, 2020.2,[iv, 51 p. :] | - |
dc.description.abstract | Nonalcoholic fatty liver disease (NAFLD) is increasing in worldwide prevalence, closely tracking the obesity epidemic, but specific pharmaceutical treatments for NAFLD are lacking. Defining the key molecular pathways underlying the pathogenesis of NAFLD is essential for developing new drugs. In this study I demonstrate that inhibition of gut-derived serotonin (GDS) synthesis ameliorates hepatic steatosis through a reduction in liver serotonin receptor 2A (HTR2A) signaling. Local serotonin concentrations in the portal blood, which can directly travel to and affect the liver, are selectively increased by high-fat diet (HFD) feeding in mice. Both gut-specific Tph1 knockout mice and liver-specific Htr2a knockout mice are resistant to HFD-induced hepatic steatosis, without affecting systemic energy homeostasis. Moreover, selective HTR2A antagonist treatment prevents HFD-induced hepatic steatosis. Thus, the gut TPH1-liver HTR2A axis shows promise as a drug target to ameliorate NAFLD with minimal systemic metabolic effects. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Peripheral serotonin▼aHTR2A▼aNonalcoholic fatty liver disease▼aMetabolic disease▼aLiver disease | - |
dc.subject | 말초 세로토닌▼a세로토닌 수용체 2A▼a비알콜성 지방간질환▼a대사질환▼a간 질환 | - |
dc.title | Novel role of gut-derived serotonin as a hormone promoting hepatic steatosis | - |
dc.title.alternative | 지방간 형성을 촉진하는 호르몬으로 작용하는 장에서 유래한 세로토닌의 신규 역할에 대한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학대학원, | - |
dc.contributor.alternativeauthor | 최원석 | - |
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