DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Park, Su-Hyung | - |
dc.contributor.advisor | 박수형 | - |
dc.contributor.author | Kim, Chang Gon | - |
dc.date.accessioned | 2021-05-11T19:43:28Z | - |
dc.date.available | 2021-05-11T19:43:28Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=907103&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/283566 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 의과학대학원, 2020.2,[87 p. :] | - |
dc.description.abstract | Although immune checkpoint blockade therapies have demonstrated clinical efficacy in cancer treatment, harnessing this strategy is largely encumbered by resistance in multiple cancer settings. Here, I show that tumor-infiltrating T cells are severely exhausted in the microsatellite stable (MSS) colorectal cancer (CRC), a representative example of PD-1 blockade–resistant tumors. In MSS CRC, I found wound healing signature to be up-regulated and that T cell exhaustion is driven by vascular endothelial growth factor-A (VEGF-A). I report that VEGF-A induces the expression of transcription factor TOX in T cells to drive exhaustion-specific transcription program in T cells. Using a combination of in vitro, ex vivo, and in vivo mouse studies, I demonstrate that combined blockade of PD-1 and VEGF-A restores the antitumor functions of T cells, resulting in better control of MSS CRC tumors. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Programmed cell death protein 1▼aT cells▼aExhaustion▼aVascular endothelial growth factor-A▼aColorectal cancer▼aTOX | - |
dc.subject | 프로그램된 세포 사멸 단백질 1▼aT 세포▼a탈진▼a혈관 내피 성장 인자 A▼a결장암▼a톡스 | - |
dc.title | Role of VEGF-A in T-cell exhaustion of microsatellite stable colorectal cancers | - |
dc.title.alternative | 현미부수체 안정성 결장암의 T 세포 탈진에서 혈관내피세포성장인자의 역할 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :의과학대학원, | - |
dc.contributor.alternativeauthor | 김창곤 | - |
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