DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Hong, Sungwoo | - |
dc.contributor.advisor | 홍승우 | - |
dc.contributor.author | Kim, Namhoon | - |
dc.date.accessioned | 2021-05-11T19:42:58Z | - |
dc.date.available | 2021-05-11T19:42:58Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=907050&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/283539 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 화학과, 2020.2,[i, 110 p. :] | - |
dc.description.abstract | Part 1. Regioselective palladium(II)-catalyzed aerobic oxidative Heck-type C3 alkenylation of sulfocoumarins. An efficient method for the direct C-H olefination of sulfcoumarins with a wide range of alkenes is developed. Moreover, $O_2$ was successfully utilized as the sole oxidant for the oxidative Heck reaction. This approach enables the rapid generation of various 3-alkenylated sulfocumarins. Part 2. Visible-light-induced remote C($sp^3$)-H pyridylation of sulfonamides and carboxamides. Visible-light-induced site-selective C($sp^3$)–H pyridylation of sulfonamides and carboxamides has been accomplished using N-amidopyridinium salts as both amido radical precursors and pyridine sources under metalfree, mild reaction conditions. The N-centered radicals generated by the single-electron reduction of Namidopyridinium substrates undergo selective 1,5-hydrogen atom transfer (HAT) to form alkyl radical intermediates. Remarkably, excellent C4-selectivity in radical trapping with pyridinium salts is observed for the generated primary, secondary, and tertiary alkyl radicals to ultimately provide synthetically valuable $\delta$-pyridyl sulfonamides and $\gamma$-pyridyl carboxamides. The utility of this powerful platform is further demonstrated by offering a practical approach for the late-stage functionalization of complex amide derivatives. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Sulfocoumarin▼aPyridine▼aPalladium▼aVisible-light▼aC-H functionalization▼aSite-selective | - |
dc.subject | 설포큐마린▼a피리딘▼a팔라듐▼a가시광선▼a탄소-수소 활성화▼a위치선택 | - |
dc.title | Site-selective C-H functionalization of sulfocoumarin and pyridine derivatives | - |
dc.title.alternative | 설포큐마린과 피리딘 유도체의 위치선택적 탄소-수소 기능화 반응에 대한 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :화학과, | - |
dc.contributor.alternativeauthor | 김남훈 | - |
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