Protective effects of dithiol malonate derivatives on carbon tetrachloride induced hepatotoxicity in primary culture of adult rat hepatocytes = 일차 간세포 배양에서 사염화탄소에 의해 발생하는 간독성에 대한 Dithiol malonate 유도체의 보호작용에 관한 연구

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The effect of Dithiol Malonate Derivatives (DMDs) on microsomal enzyme activities, protein and RNA synthesis, and hepatotoxicity induced by carbon tetrachloride were invesdtigated in primary culture of adult rat hepatocytes. DMDs had no effect on total cytochrome P-450 content and associated drug metabolizing enzyme activities, such as ethoxycoumarin O-deethylasee, aryl hydrocarbon hydroxylase. Also, DMNDs had no effect on protein and RNA synthesis in primary culture of rat hepatocytes. Protective effects of DMDs on hepatotoxicities induced by carbon tetrachloride, such as LDH release, lipid peroxidation, fatty liver (accumulation of triacylglyceride), inhibition of protein synthesis were studied. DMDs showed protective effect on LDH release and DMDs supressed the increased peroxidation produced by carbon tetrachloride. It was found that DMDs had protective effect on the accumulation of cellular triacylglycerol produced by carbon tetrachloride and on the inhibitory action of carbon tetrachloride on triacylglycerol secretion. Although DMDs recovered the protein synthesis decreased by carbon tetrachloride.
Advisors
Yang, Kyu-Hwan양규환
Description
한국과학기술원 : 생물공학과,
Publisher
한국과학기술원
Issue Date
1989
Identifier
66673/325007 / 000871396
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생물공학과, 1989.2, [ [vi], 59 p. ]

URI
http://hdl.handle.net/10203/28326
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=66673&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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