Effects of minoxidil on immune system = Minoxidil의 생체면역계에 대한 영향

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The immunomodulation effects of minoxidil were investigated using various parameters. Minoxidil did not cause any modulation of in vitro antibody response to lipopolysaccaride(LPS), DNP-Ficoll and sheep red blood cell (SBRC). But minoxidil increased mitogen, LPS and concanavalin A (Con A), - induced lymphoproliferation at relatively low concentration and did not have any increase of phytohemagglutinin (PHA)-induced proliferative response. Meanwhile the coculture with rat hepatocytes was used to elucidate immunomodulation of metabolites minoxidil which could be produced by hepatocytes. In coculture system, minoxidil enhanced T-dependent antibody response to SRBC by dose-dependence but lost enhancing effect in in vitro mitogen - induced lymphoproliferative assay. In addition, in vivo exposure of minoxidil to mice did not caused any immunomodulation effects which were presented in vitro coculture system. These results suggest that metabolites of minoxidil have immunomodulation on T-cell specific response and minoxidil itself affect mitogen - induced proliferative response although mechanism of immunomodulation is not well-known.
Advisors
Yang, Kyu-Hwan양규환
Description
한국과학기술원 : 생물공학과,
Publisher
한국과학기술원
Issue Date
1989
Identifier
66649/325007 / 000871704
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생물공학과, 1989.2, [ vii, 53 p. ]

URI
http://hdl.handle.net/10203/28312
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=66649&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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