Staufen1 regulates DNA-demethylating agent-induced cell death via double-stranded RNA expression control in colorectal cancer cells대장암에서 Staufen1에 의한 DNA-demethylating agent로부터 유도된 세포사멸 조절 연구

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dc.contributor.advisorKim, Yoo Sik-
dc.contributor.advisor김유식-
dc.contributor.authorKu, Yongsuk-
dc.date.accessioned2021-05-11T19:32:14Z-
dc.date.available2021-05-11T19:32:14Z-
dc.date.issued2019-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=875272&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/282979-
dc.description학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2019.8,[iii, 21 p. :]-
dc.description.abstract5'-AZA-CdR (decitabine), known as a DNA-demethylation agent, is used as an anticancer agent for cancer such as colorectal cancer and acute myeloid leukemia. Recent studies have shown that decitabine abrogates the methylation of DNA regions that encoded endogenous retroviruses (ERVs) in cancer cells, resulting in an abnormal increase in intracellular ERV expression. Besides, these ERVs can make dsRNA structure form, leading to immune responses in cancer cells leading to apoptosis. However, unlike previous study results, some patients are not susceptible to chemotherapy. Moreover, dsRNAs that are abnormally increased by decitabine can interact with other dsRNA-binding proteins. Therefore there would be another critical factor that could exist. Through screening experiments to confirm the interaction effect between ERV and dsRNA binding proteins, we identified staufen1 as a protein that has a significant impact on the apoptotic mechanism of decitabine. Based on the results of this study, we expect to be able to realize patient-customized treatment with anticancer drugs.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectDecitabine▼aDNA methylation▼astaufen1▼aanti-cancer drug▼aendogenous retrovirus▼adouble-stranded RNA-
dc.subject데시타빈▼aDNA 메틸화▼aStaufen1▼a항암제▼a내인성 레트로 바이러스▼a이중가닥 RNA-
dc.titleStaufen1 regulates DNA-demethylating agent-induced cell death via double-stranded RNA expression control in colorectal cancer cells-
dc.title.alternative대장암에서 Staufen1에 의한 DNA-demethylating agent로부터 유도된 세포사멸 조절 연구-
dc.typeThesis(Master)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :생명화학공학과,-
dc.contributor.alternativeauthor구용석-
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