DC Field | Value | Language |
---|---|---|
dc.contributor.author | Go, Eunbyeol | ko |
dc.contributor.author | Yoo, Su-Jin | ko |
dc.contributor.author | Choi, Suyoung | ko |
dc.contributor.author | Sun, Pureum | ko |
dc.contributor.author | Jung, Min Kyung | ko |
dc.contributor.author | Kwon, Somin | ko |
dc.contributor.author | Heo, Bu Yeon | ko |
dc.contributor.author | Kim, Yeeun | ko |
dc.contributor.author | Kang, Ju-Gyeong | ko |
dc.contributor.author | Kim, Jinhyun | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Kang, Seong Wook | ko |
dc.contributor.author | Kwon, Jaeyul | ko |
dc.date.accessioned | 2021-05-04T09:10:13Z | - |
dc.date.available | 2021-05-04T09:10:13Z | - |
dc.date.created | 2021-05-04 | - |
dc.date.created | 2021-05-04 | - |
dc.date.created | 2021-05-04 | - |
dc.date.issued | 2021-04 | - |
dc.identifier.citation | CELLS, v.10, no.4 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | http://hdl.handle.net/10203/282797 | - |
dc.description.abstract | Rheumatoid arthritis (RA) is a common autoimmune disease characterized by immune cell infiltration of the synovium, leading to the loss of cartilage, bone, and joint function. Although regulatory T (T-reg) cells are thought to modulate the initiation and progression of RA, a consensus has yet to be reached regarding the function and composition of T-reg cells in RA patients. To address these discrepancies, we analyzed not only the total T-reg frequency but also that of T-reg subpopulations in the peripheral blood of RA patients and healthy controls by flow cytometry. We found that the total T-reg population was not significantly different between RA and control subjects. However, the effector T-reg cell subgroup, defined as CD45RA(-)CD25(hi), showed markedly decreased frequency in RA patients. In addition, the total T-reg population from RA patients showed a significant decline in the expression of CD25. Both the naive and effector T-reg subgroups also showed marked reduction of CD25 expression in RA patients compared to controls. These data suggest that the decreased frequency of effector T-reg cells and overall reduction of CD25 expression in T-reg cells in the peripheral blood may be evidence of altered T-reg homeostasis associated with RA pathogenesis. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | Peripheral Blood from Rheumatoid Arthritis Patients Shows Decreased T-reg CD25 Expression and Reduced Frequency of Effector T-reg Subpopulation | - |
dc.type | Article | - |
dc.identifier.wosid | 000642896500001 | - |
dc.identifier.scopusid | 2-s2.0-85105161231 | - |
dc.type.rims | ART | - |
dc.citation.volume | 10 | - |
dc.citation.issue | 4 | - |
dc.citation.publicationname | CELLS | - |
dc.identifier.doi | 10.3390/cells10040801 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Go, Eunbyeol | - |
dc.contributor.nonIdAuthor | Yoo, Su-Jin | - |
dc.contributor.nonIdAuthor | Choi, Suyoung | - |
dc.contributor.nonIdAuthor | Sun, Pureum | - |
dc.contributor.nonIdAuthor | Kwon, Somin | - |
dc.contributor.nonIdAuthor | Heo, Bu Yeon | - |
dc.contributor.nonIdAuthor | Kim, Yeeun | - |
dc.contributor.nonIdAuthor | Kim, Jinhyun | - |
dc.contributor.nonIdAuthor | Kang, Seong Wook | - |
dc.contributor.nonIdAuthor | Kwon, Jaeyul | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | regulatory T cells | - |
dc.subject.keywordAuthor | CD25 | - |
dc.subject.keywordAuthor | Foxp3 | - |
dc.subject.keywordAuthor | effector regulatory T cells | - |
dc.subject.keywordAuthor | CD127 | - |
dc.subject.keywordAuthor | na& | - |
dc.subject.keywordAuthor | #239 | - |
dc.subject.keywordAuthor | ve regulatory T cells | - |
dc.subject.keywordAuthor | CD45RA | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.