A mechanogenetic role for the actomyosin complex in branching morphogenesis of epithelial organs

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 32
  • Download : 0
The actomyosin complex plays crucial roles in various life processes by balancing the forces generated by cellular components. In addition to its physical function, the actomyosin complex participates in mechanotransduction. However, the exact role of actomyosin contractility in force transmission and the related transcriptional changes during morphogenesis are not fully understood. Here, we report a mechanogenetic role of the actomyosin complex in branching morphogenesis using an organotypic culture system of mouse embryonic submandibular glands. We dissected the physical factors arranged by characteristic actin structures in developing epithelial buds and identified the spatial distribution of forces that is essential for buckling mechanism to promote the branching process. Moreover, the crucial genes required for the distribution of epithelial progenitor cells were regulated by YAP and TAZ through a mechanotransduction process in epithelial organs. These findings are important for our understanding of the physical processes involved in the development of epithelial organs and provide a theoretical background for developing new approaches for organ regeneration.
Publisher
COMPANY BIOLOGISTS LTD
Issue Date
2021-03
Language
English
Article Type
Article
Citation

DEVELOPMENT, v.148, no.6

ISSN
0950-1991
DOI
10.1242/dev.190785
URI
http://hdl.handle.net/10203/282564
Appears in Collection
RIMS Journal Papers
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0