SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In the current review, we describe SARS-CoV-2-specific CD4(+) and CD8(+) T-cell responses in acute and convalescent COVID-19 patients. We also discuss the relationships between COVID-19 severity and SARS-CoV-2-specific T-cell responses and summarize recent reports regarding SARS-CoV-2-reactive T cells in SARS-CoV-2-unexposed individuals. These T cells may be cross-reactive cells primed by previous infection with human common-cold coronaviruses. Finally, we outline SARS-CoV-2-specific T-cell responses in the context of vaccination. A better understanding of SARS-CoV-2-specific T-cell responses is needed to develop effective vaccines and therapeutics.
Publisher
KOREA ASSOC IMMUNOLOGISTS
Issue Date
2021-02
Language
English
Article Type
Review
Citation

IMMUNE NETWORK, v.21, no.1

ISSN
1598-2629
DOI
10.4110/in.2021.21.e2
URI
http://hdl.handle.net/10203/282298
Appears in Collection
MSE-Journal Papers(저널논문)
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