DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yujin | ko |
dc.contributor.author | Jung, Yoonji | ko |
dc.contributor.author | Jeong, Dae-Eun | ko |
dc.contributor.author | Hwang, Wooseon | ko |
dc.contributor.author | Ham, Seokjin | ko |
dc.contributor.author | 박혜은 | ko |
dc.contributor.author | Kwon, Sujeong | ko |
dc.contributor.author | Ashraf, Jasmine M. | ko |
dc.contributor.author | Murphy, Coleen T. | ko |
dc.contributor.author | Lee, Seung-Jae, V | ko |
dc.date.accessioned | 2021-03-30T01:50:22Z | - |
dc.date.available | 2021-03-30T01:50:22Z | - |
dc.date.created | 2021-03-30 | - |
dc.date.created | 2021-03-30 | - |
dc.date.issued | 2021-03 | - |
dc.identifier.citation | JOURNAL OF CELL BIOLOGY, v.220, no.5 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.uri | http://hdl.handle.net/10203/282189 | - |
dc.description.abstract | A hallmark of aging is immunosenescence, a decline in immune functions, which appeared to be inevitable in living organisms, including Caenorhabditis elegans. Here, we show that genetic inhibition of the DAF-2/insulin/IGF-1 receptor drastically enhances immunocompetence in old age in C. elegans. We demonstrate that longevity-promoting DAF-16/FOXO and heat-shock transcription factor 1 (HSF-1) increase immunocompetence in old daf-2(-) animals. In contrast, p38 mitogen-activated protein kinase 1 (PMK-1), a key determinant of immunity, is only partially required for this rejuvenated immunity. The up-regulation of DAF-16/FOXO and HSF-1 decreases the expression of the zip-10/bZIP transcription factor, which in turn down-regulates INS7, an agonistic insulin-like peptide, resulting in further reduction of insulin/IGF-1 signaling (IIS). Thus, reduced IIS prevents immune aging via the up-regulation of anti-aging transcription factors that modulate an endocrine insulin-like peptide through a feedforward mechanism. Because many functions of 115 are conserved across phyla, our study may lead to the development of strategies against immune aging in humans. | - |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.title | Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop | - |
dc.type | Article | - |
dc.identifier.wosid | 000626391900001 | - |
dc.identifier.scopusid | 2-s2.0-85102705308 | - |
dc.type.rims | ART | - |
dc.citation.volume | 220 | - |
dc.citation.issue | 5 | - |
dc.citation.publicationname | JOURNAL OF CELL BIOLOGY | - |
dc.identifier.doi | 10.1083/jcb.202006174 | - |
dc.contributor.localauthor | Lee, Seung-Jae, V | - |
dc.contributor.nonIdAuthor | Lee, Yujin | - |
dc.contributor.nonIdAuthor | Jeong, Dae-Eun | - |
dc.contributor.nonIdAuthor | Hwang, Wooseon | - |
dc.contributor.nonIdAuthor | Ham, Seokjin | - |
dc.contributor.nonIdAuthor | Ashraf, Jasmine M. | - |
dc.contributor.nonIdAuthor | Murphy, Coleen T. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | DEPENDENT REGULATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | DAUER FORMATION | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | DAF-2 | - |
dc.subject.keywordPlus | RESISTANCE | - |
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