DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jinjoo | ko |
dc.contributor.author | Keum, Hyeongseop | ko |
dc.contributor.author | Kim, Hansol | ko |
dc.contributor.author | Yu, Byeongjun | ko |
dc.contributor.author | Jung, Wonsik | ko |
dc.contributor.author | Whang, Changhee | ko |
dc.contributor.author | Seo, Changjin | ko |
dc.contributor.author | Park, Ji Ho | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.date.accessioned | 2021-03-26T02:18:02Z | - |
dc.date.available | 2021-03-26T02:18:02Z | - |
dc.date.created | 2020-04-08 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.citation | JOURNAL OF DRUG TARGETING, v.21, no.7-8, pp.780 - 788 | - |
dc.identifier.issn | 1061-186X | - |
dc.identifier.uri | http://hdl.handle.net/10203/281919 | - |
dc.description.abstract | Despite the wide utility of gold nanorods (GNRs) in biomedical fields, only a few methods for modifying or coating the surface of GNRs suitable for biomedical applications are available. In this study, we report a new facile method that enables formation of an ultra-thin (nanometre-thickness) siloxane layer on GNRs with anti-biofouling properties and ligand functionalisation ability. A triblock random copolymer, poly(TMSMA-r-PEGMA-r-NAS), was used to coat GNRs. An ultrathin polymeric shell was formed surrounding GNRs through acid-catalysed crosslinking of silicates of TMSMA. The polymer-coated GNRs (p-GNRs) exhibited high colloidal stability in biological solutions of high ionic strength and long-term stability superior to that of PEG(2k)-S-GNRs. The functionalities of NAS were demonstrated using two methods for conjugating targeting ligands and loading doxorubicin via electrostatic interactions. The ligand-specific cancer-targeting ability and combinatorial chemo-photothermal anticancer effects were validated in vitro and in vivo, suggesting their potential utility in various fields. | - |
dc.language | English | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Gold nanorods with an ultrathin anti-biofouling siloxane layer for combinatorial anticancer therapy | - |
dc.type | Article | - |
dc.identifier.wosid | 000520358500001 | - |
dc.identifier.scopusid | 2-s2.0-85081744292 | - |
dc.type.rims | ART | - |
dc.citation.volume | 21 | - |
dc.citation.issue | 7-8 | - |
dc.citation.beginningpage | 780 | - |
dc.citation.endingpage | 788 | - |
dc.citation.publicationname | JOURNAL OF DRUG TARGETING | - |
dc.identifier.doi | 10.1080/1061186X.2020.1737086 | - |
dc.contributor.localauthor | Park, Ji Ho | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Anticancer therapy | - |
dc.subject.keywordAuthor | anti-biofouling coating | - |
dc.subject.keywordAuthor | gold nanorods | - |
dc.subject.keywordAuthor | photothermal therapy | - |
dc.subject.keywordAuthor | siloxane polymers | - |
dc.subject.keywordPlus | IRON-OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | PHOTOTHERMAL THERAPY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SILICA | - |
dc.subject.keywordPlus | IMMUNITY | - |
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