A systematic review of chromogranin A (CgA) and its biomedical applications, unveiling its structure-related functions

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dc.contributor.authorChoi, Kyuhyungko
dc.contributor.authorHan, Manhyukko
dc.contributor.authorKim, Seung Joongko
dc.date.accessioned2021-03-22T08:30:25Z-
dc.date.available2021-03-22T08:30:25Z-
dc.date.created2021-02-18-
dc.date.created2021-02-18-
dc.date.issued2021-03-
dc.identifier.citationJOURNAL OF THE KOREAN PHYSICAL SOCIETY, v.78, no.5, pp.427 - 441-
dc.identifier.issn0374-4884-
dc.identifier.urihttp://hdl.handle.net/10203/281742-
dc.description.abstractChromogranin A (CgA), which is an intrinsically disordered protein that belongs to the granin family, was first discovered in the bovine adrenal medulla, and later identified in various organs. Under certain physiological conditions, CgA is cleaved into functionally diverse peptides, such as vasostatin-1, pancreastatin, and catestatin. In this review, we first describe the historical and systematic challenges for elucidating the molecular structures of CgA and its derived peptides and give a perspective of utilizing emerging techniques through integrative approaches. Subsequently, we review specific biological processes associated with CgA and its derived peptides in the neuroendocrine, immune, and digestive systems. Finally, we discuss biomedical applications of CgA as a biomarker, suggesting future directions toward translational and precision medicine.-
dc.languageEnglish-
dc.publisher한국물리학회-
dc.titleA systematic review of chromogranin A (CgA) and its biomedical applications, unveiling its structure-related functions-
dc.typeArticle-
dc.identifier.wosid000608953000005-
dc.identifier.scopusid2-s2.0-85100162234-
dc.type.rimsART-
dc.citation.volume78-
dc.citation.issue5-
dc.citation.beginningpage427-
dc.citation.endingpage441-
dc.citation.publicationnameJOURNAL OF THE KOREAN PHYSICAL SOCIETY-
dc.identifier.doi10.1007/s40042-020-00042-6-
dc.identifier.kciidART002693487-
dc.contributor.localauthorKim, Seung Joong-
dc.contributor.nonIdAuthorChoi, Kyuhyung-
dc.contributor.nonIdAuthorHan, Manhyuk-
dc.description.isOpenAccessN-
dc.type.journalArticleReview-
dc.subject.keywordAuthorChromogranin A-
dc.subject.keywordAuthorVasostatin-1-
dc.subject.keywordAuthorCatestatin-
dc.subject.keywordAuthorBiomarker-
dc.subject.keywordAuthorTranslational medicine-
dc.subject.keywordPlusINTRINSICALLY DISORDERED PROTEINS-
dc.subject.keywordPlusMOLECULAR-DYNAMICS SIMULATIONS-
dc.subject.keywordPlusCHEMICAL CROSS-LINKING-
dc.subject.keywordPlusINTEGRATIVE STRUCTURE-
dc.subject.keywordPlusPROSTATE-CANCER-
dc.subject.keywordPlusSECRETOGRANIN-II-
dc.subject.keywordPlusPROTEOLYTIC CLEAVAGE-
dc.subject.keywordPlusNEUROENDOCRINE CELLS-
dc.subject.keywordPlusREGULATORY PEPTIDES-
dc.subject.keywordPlusSECONDARY STRUCTURE-
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PH-Journal Papers(저널논문)
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