Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in urinary bladder cancer방광암 모델에서 수용성 혈관생성인자수용체-3의 림프관 형성 및 림프절로의 전이 억제 효과

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dc.contributor.advisorKoh, Gou-Young-
dc.contributor.advisor고규영-
dc.contributor.authorYang, Han-Seul-
dc.contributor.author양한슬-
dc.date.accessioned2011-12-12T08:55:19Z-
dc.date.available2011-12-12T08:55:19Z-
dc.date.issued2010-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=419058&flag=dissertation-
dc.identifier.urihttp://hdl.handle.net/10203/28117-
dc.description학위논문(석사) - 한국과학기술원 : 생명과학과, 2010.2, [ v, 53 p. ]-
dc.description.abstractHigh recurrence and metastasis is a hallmark of urinary bladder cancer, yet the relationship between lymphangiogenesis or lymphatic metastasis and urinary bladder cancer is unknown. Here, we identified a profound lymphangiogenesis in orthotopic urinary bladder cancer (OUBC) mice, a model generated by implantation of MBT-2 cell to urinary bladder. OUBC mice displayed massive infiltration of CD11b+/Gr-1+ tumor-associated macrophages (TAM) cells and dissemination of the OUBC cells in sentinel lymph nodes (SLN). Interestingly, CD11b+/Gr-1+ TAM are a source of lymphangiogenic growth factors such as vascular endothelial growth factor (VEGF)-C and VEGF-D (VEGF-C/D). The blockade of VEGF-C/D with soluble VEGF receptor-3 and the depletion of CD11b+/Gr-1+ TAM with clodronate liposome markedly inhibited OUBC-induced lymphangiogenesis and lymphatic metastasis to SLN. Our results indicate that VEGF-C/D are main factors for the OUBC-induced lymphangiogenesis and lymph node metastasis; moreover, CD11b+/Gr-1+ TAM could be responsible for the OUBC-induced lymphangiogenesis and lymph node metastasis by producing VEGF-C/D. These findings provide additional therapeutic target to lymphatic metastasis in the patients with urinary bladder cancer.eng
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectVEGF receptor-3-
dc.subjectVEGF-C-
dc.subjectLymphatic metastasis-
dc.subjectLymphangiogenesis-
dc.subjectCD11b+/Gr-1+ TAMs-
dc.subjectCD11b+/Gr-1+ 암대식세포-
dc.subject혈관생성인자수용체-3-
dc.subject혈관생성인자-C-
dc.subject림프절 전이-
dc.subject림프관 형성-
dc.titleSoluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in urinary bladder cancer-
dc.title.alternative방광암 모델에서 수용성 혈관생성인자수용체-3의 림프관 형성 및 림프절로의 전이 억제 효과-
dc.typeThesis(Master)-
dc.identifier.CNRN419058/325007 -
dc.description.department한국과학기술원 : 생명과학과, -
dc.identifier.uid020088091-
dc.contributor.localauthorKoh, Gou-Young-
dc.contributor.localauthor고규영-
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