DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Koh, Gou-Young | - |
dc.contributor.advisor | 고규영 | - |
dc.contributor.author | Yang, Han-Seul | - |
dc.contributor.author | 양한슬 | - |
dc.date.accessioned | 2011-12-12T08:55:19Z | - |
dc.date.available | 2011-12-12T08:55:19Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=419058&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/28117 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명과학과, 2010.2, [ v, 53 p. ] | - |
dc.description.abstract | High recurrence and metastasis is a hallmark of urinary bladder cancer, yet the relationship between lymphangiogenesis or lymphatic metastasis and urinary bladder cancer is unknown. Here, we identified a profound lymphangiogenesis in orthotopic urinary bladder cancer (OUBC) mice, a model generated by implantation of MBT-2 cell to urinary bladder. OUBC mice displayed massive infiltration of CD11b+/Gr-1+ tumor-associated macrophages (TAM) cells and dissemination of the OUBC cells in sentinel lymph nodes (SLN). Interestingly, CD11b+/Gr-1+ TAM are a source of lymphangiogenic growth factors such as vascular endothelial growth factor (VEGF)-C and VEGF-D (VEGF-C/D). The blockade of VEGF-C/D with soluble VEGF receptor-3 and the depletion of CD11b+/Gr-1+ TAM with clodronate liposome markedly inhibited OUBC-induced lymphangiogenesis and lymphatic metastasis to SLN. Our results indicate that VEGF-C/D are main factors for the OUBC-induced lymphangiogenesis and lymph node metastasis; moreover, CD11b+/Gr-1+ TAM could be responsible for the OUBC-induced lymphangiogenesis and lymph node metastasis by producing VEGF-C/D. These findings provide additional therapeutic target to lymphatic metastasis in the patients with urinary bladder cancer. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | VEGF receptor-3 | - |
dc.subject | VEGF-C | - |
dc.subject | Lymphatic metastasis | - |
dc.subject | Lymphangiogenesis | - |
dc.subject | CD11b+/Gr-1+ TAMs | - |
dc.subject | CD11b+/Gr-1+ 암대식세포 | - |
dc.subject | 혈관생성인자수용체-3 | - |
dc.subject | 혈관생성인자-C | - |
dc.subject | 림프절 전이 | - |
dc.subject | 림프관 형성 | - |
dc.title | Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in urinary bladder cancer | - |
dc.title.alternative | 방광암 모델에서 수용성 혈관생성인자수용체-3의 림프관 형성 및 림프절로의 전이 억제 효과 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 419058/325007 | - |
dc.description.department | 한국과학기술원 : 생명과학과, | - |
dc.identifier.uid | 020088091 | - |
dc.contributor.localauthor | Koh, Gou-Young | - |
dc.contributor.localauthor | 고규영 | - |
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