Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in urinary bladder cancer = 방광암 모델에서 수용성 혈관생성인자수용체-3의 림프관 형성 및 림프절로의 전이 억제 효과

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 457
  • Download : 0
High recurrence and metastasis is a hallmark of urinary bladder cancer, yet the relationship between lymphangiogenesis or lymphatic metastasis and urinary bladder cancer is unknown. Here, we identified a profound lymphangiogenesis in orthotopic urinary bladder cancer (OUBC) mice, a model generated by implantation of MBT-2 cell to urinary bladder. OUBC mice displayed massive infiltration of CD11b+/Gr-1+ tumor-associated macrophages (TAM) cells and dissemination of the OUBC cells in sentinel lymph nodes (SLN). Interestingly, CD11b+/Gr-1+ TAM are a source of lymphangiogenic growth factors such as vascular endothelial growth factor (VEGF)-C and VEGF-D (VEGF-C/D). The blockade of VEGF-C/D with soluble VEGF receptor-3 and the depletion of CD11b+/Gr-1+ TAM with clodronate liposome markedly inhibited OUBC-induced lymphangiogenesis and lymphatic metastasis to SLN. Our results indicate that VEGF-C/D are main factors for the OUBC-induced lymphangiogenesis and lymph node metastasis; moreover, CD11b+/Gr-1+ TAM could be responsible for the OUBC-induced lymphangiogenesis and lymph node metastasis by producing VEGF-C/D. These findings provide additional therapeutic target to lymphatic metastasis in the patients with urinary bladder cancer.
Advisors
Koh, Gou-Youngresearcher고규영researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2010
Identifier
419058/325007  / 020088091
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2010.2, [ v, 53 p. ]

Keywords

VEGF receptor-3; VEGF-C; Lymphatic metastasis; Lymphangiogenesis; CD11b+/Gr-1+ TAMs; CD11b+/Gr-1+ 암대식세포; 혈관생성인자수용체-3; 혈관생성인자-C; 림프절 전이; 림프관 형성

URI
http://hdl.handle.net/10203/28117
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=419058&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0