Characterization of cyclophilin 40 in drosophila melanogaster = 초파리 Cyclophilin 40 유전자의 기능 연구

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Cyclophilin 40 (Cyp40), a 40 kDa cyclosporin A-binding immunophilin first identified in association with inactivated estrogen receptors, appears to have a diverse array of physiological functions. To understand the biological functions of Cyp40 in $\It{Drosophila}$, I generated and characterized gain-of-function and loss-of-function mutants for $\It{dCyp40}$. Overexpression or suppression of $\It{dCyp40}$ exhibited no phenotypes in eyes, wings and thoraxes. The $\It{dCyp40}$ null mutants were viable and fertile, but with reduced lifespan at high temperature whereas overexpression of $\It{dCyp40}$ extended fly longevity at the same condition, suggesting $\It{dCyp40}$ is a heat-responsive protein. Unexpectedly, neither cell cycle arrest nor apoptosis was induced by $\It{dCyp40}$ overexpression or loss-of-function. Moreover, $\It{dCyp40}$ also did not rescue $\It{PINK1^{B9}}$ mutant phenotypes in the wing and thorax. Taken together, using Drosophila system, I have developed invaluable tools to study the physiological functions of Cyp40.
Advisors
Chung, Jong-Kyeongresearcher정종경researcher
Description
한국과학기술원 : 생명과학과,
Publisher
한국과학기술원
Issue Date
2010
Identifier
419033/325007  / 020088075
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명과학과, 2010.2, [ v, 47 p. ]

Keywords

Cyclophilin 40; Drosophila; 초파리; Cyclophilin 40

URI
http://hdl.handle.net/10203/28111
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=419033&flag=dissertation
Appears in Collection
BS-Theses_Master(석사논문)
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